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Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing-factor

Academic Article
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Overview

authors

  • Cole, B. J.
  • Koob, George

publication date

  • December 1988

journal

  • Journal of Pharmacology and Experimental Therapeutics  Journal

abstract

  • A series of experiments examined the effects of systemic administration of the beta adrenergic antagonist propranolol on the enhanced conditioned fear and the locomotor hyperactivity induced by central administration of corticotropin releasing factor (CRF). In Experiment 1, CRF (0.5 microgram) was shown to reduce responding in both the conditioned stimulus (cs) and the pre-cs components of an on-the-base-line conditioned suppression schedule. The effects of CRF on cs, but not pre-cs responding were antagonized by propranolol, at doses (2.5, 5.0 and 10.0 mg/kg) that did not affect responding themselves. This reversal of the anxiogenic effects of CRF by propranolol was specific to l- and not d-propranolol, showing that it did not result from nonspecific membrane stabilization. Propranolol also failed to reverse the reduced responding induced by the benzodiazepine inverse agonist FG 7142 in this schedule. In Experiment 2, propranolol was shown to potentiate the locomotor hyperactivity induced by CRF in a familiar photocell cage. These results suggest that activation of beta adrenoceptors may be an important mechanism in the behavioral inhibition induced by CRF, and that the neurochemical mechanisms that underlie the "anxiogenic" and the "activating" behavioral effects of CRF are neuropharmacologically distinct.

subject areas

  • Animals
  • Anxiety
  • Carbolines
  • Conditioning (Psychology)
  • Corticotropin-Releasing Hormone
  • Fear
  • Flumazenil
  • Locus Coeruleus
  • Male
  • Motor Activity
  • Propranolol
  • Rats
  • Receptors, Adrenergic, beta
  • Receptors, Serotonin
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0022-3565

PubMed ID

  • 2849675
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Additional Document Info

start page

  • 902

end page

  • 910

volume

  • 247

issue

  • 3

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