Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Ait-Azzouzene, D.
  • Gendron, M. C.
  • Houdayer, M.
  • Langkopf, A.
  • Burki, K.
  • Nemazee, David
  • Kanellopoulos-Langevin, C.

publication date

  • September 1998

journal

  • Journal of Immunology  Journal

abstract

  • Although genetically different from its mother, a mammalian fetus bearing paternal alloantigens is normally not rejected. To investigate one of the many possible mechanisms involved in this important biologic phenomenon, we analyzed the consequences of fetal alloantigen recognition on maternal B lymphocytes. We used transgenic mice expressing a unique B cell receptor with a relatively high affinity for the MHC class I molecule H-2Kk on most B lymphocytes. We provide the first evidence for an alloantigen-specific B cell deletion in the spleens and bone marrow of transgenic mothers bearing H-2Kk-positive fetuses. This highly reproducible deletion affects < or =80% of Id-bearing B cells, starts at midpregnancy, and is only observed until term. Such a specific maternal B cell deletion could contribute to the success of the fetal allograft.

subject areas

  • Animals
  • B-Lymphocyte Subsets
  • Bone Marrow Cells
  • Clonal Deletion
  • Crosses, Genetic
  • Epitopes
  • Female
  • Flow Cytometry
  • H-2 Antigens
  • Immunoglobulin M
  • Lymphocyte Count
  • Lymphopenia
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Pregnancy
  • Pregnancy, Animal
  • Sex Characteristics
  • Spleen
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 9743323
scroll to property group menus

Additional Document Info

start page

  • 2677

end page

  • 2683

volume

  • 161

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support