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Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus-accumbens

Academic Article
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Overview

authors

  • Rassnick, S.
  • Pulvirenti, Luigi
  • Koob, George

publication date

  • October 1992

journal

  • Psychopharmacology  Journal

abstract

  • The purpose of this study was to assess the role of endogenous dopamine and glutamate systems within the nucleus accumbens in modulating responses for oral ethanol reinforcements (10% w/v) in a free-choice operant task. Pretreatment with both systemic (100 micrograms/kg) and intra-nucleus accumbens microinjection of fluphenazine (2 and 4 micrograms), a dopamine receptor antagonist, significantly decreased responding for ethanol, without significantly affecting responses for water. Ethanol self-administration was also attenuated by microinjection into the nucleus accumbens of 2-amino-5-phosphopentanoic acid (AP-5, 3 and 6 micrograms), a competitive NMDA receptor antagonist. These results suggest that dopamine and glutamate neurotransmission in the nucleus accumbens may regulate ethanol self-administration and its reinforcing effects.

subject areas

  • 2-Amino-5-phosphonovalerate
  • Alcohol Drinking
  • Animals
  • Behavior, Animal
  • Dopamine Antagonists
  • Excitatory Amino Acid Antagonists
  • Fluphenazine
  • Injections
  • Male
  • Nucleus Accumbens
  • Rats
  • Rats, Wistar
  • Receptors, N-Methyl-D-Aspartate
  • Self Administration
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Research

keywords

  • DOPAMINE ANTAGONIST
  • ETHANOL SELF-ADMINISTRATION
  • NMDA ANTAGONIST
  • NUCLEUS ACCUMBENS
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Identity

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/bf02245485

PubMed ID

  • 1365677
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Additional Document Info

start page

  • 92

end page

  • 98

volume

  • 109

issue

  • 1-2

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