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Conservation of mitotic controls in fission and budding yeasts

Academic Article
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Overview

authors

  • Russell, Paul
  • Moreno, S.
  • Reed, Steven

publication date

  • April 1989

journal

  • Cell  Journal

abstract

  • In fission yeast, the initiation of mitosis is regulated by a control network that integrates the opposing activities of mitotic inducers and inhibitors. To evaluate whether this control system is likely to be conserved among eukaryotes, we have investigated whether a similar mitotic control operates in the distantly related budding yeast S. cerevisiae. We have found that the protein kinase encoded by the mitotic inhibitor gene wee1+ of fission yeast, which acts to delay mitosis, is able also to delay the initiation of mitosis when expressed in S. cerevisiae. The wee1+ activity is counteracted in S. cerevisiae by the gene product of MIH1, a newly identified gene capable of encoding a protein of MW 54,000, which is a structural and functional homolog of the cdc25+ mitotic inducer of fission yeast. Expression of wee1+ in a mih1- strain prevents the initiation of mitosis. These data indicate that important features of the cdc25+-wee1+ mitotic control network identified in S. pombe are conserved in S. cerevisiae, and therefore are also likely to be generally conserved among eukaryotic organisms.

subject areas

  • Base Sequence
  • Cell Division
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes, Fungal
  • Mitosis
  • Phenotype
  • Saccharomyces cerevisiae
  • Schizosaccharomyces
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(89)90967-7

PubMed ID

  • 2649252
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Additional Document Info

start page

  • 295

end page

  • 303

volume

  • 57

issue

  • 2

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