Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Tau protein abnormalities associated with the progression of alzheimer disease type dementia

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Haroutunian, V.
  • Davies, P.
  • Vianna, C.
  • Buxbaum, Joel
  • Purohit, D. P.

publication date

  • January 2007

journal

  • Neurobiology of Aging  Journal

abstract

  • The degree to which neurofibrillary tangles (NFT), the hallmark lesions of Alzheimer disease (AD), contribute to the development of the cognitive symptoms of AD has been debated. NFTs are comprised of abnormally phosphorylated and conformationally altered tau proteins. Conformational changes in tau have been proposed to be among the earliest neurobiological changes in AD. This study examined whether conformational changes detected by antibodies MC1 and TG3 represent early abnormalities in the disease process by assessing their presence at different stages of dementia in multiple brain regions. Postmortem specimens from several neocortical regions were examined for conformational changes in tau by ELISA in subjects [n=81] who died at different stages of cognitive impairment. Concentrations of conformationally altered tau increased with increasing dementia severity and the levels of MC1 immunoreactivity increased in the frontal cortex of mildly demented subjects before the appearance of NFT bearing neurons, suggesting that conformational alterations in tau occur early in the course of AD and its cognitive symptoms and may precede histologically identified NFTs.

subject areas

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Brain
  • Brain Chemistry
  • Disease Progression
  • Female
  • Humans
  • In Vitro Techniques
  • Male
  • Middle Aged
  • tau Proteins
scroll to property group menus

Research

keywords

  • Alzheimer disease
  • dementia
  • neurofibrillary tangles
  • tau
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0197-4580

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2005.11.001

PubMed ID

  • 16343696
scroll to property group menus

Additional Document Info

start page

  • 1

end page

  • 7

volume

  • 28

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support