recent publications
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academic article
- Feuer, R., Hassett, D. E., Whitton, J. L., Liu, F. Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology Journal of Clinical Investigation 2006 116:465-475 DOI:10.1172/jci25608 PMID:16424939
- Feuer, R., Mena, I., Pagarigan, R. R., Hassett, D. E., Whitton, J. L. Coxsackievirus replication and the cell cycle: A potential regulatory mechanism for viral persistence/latency Medical Microbiology and Immunology 2004 193:83-90 DOI:10.1007/s00430-003-0192-z PMID:12925877
- Feuer, R., Mena, I., Pagarigan, R. R., Harkins, S., Hassett, D. E., Whitton, J. L. Coxsackievirus b3 and the neonatal cns - the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease American Journal of Pathology 2003 163:1379-1393 DOI:10.1016/s0002-9440(10)63496-7 PMID:14507646
- Zhang, J., Silvestri, N., Whitton, J. L., Hassett, D. E. Neonates mount robust and protective adult-like cd8(+)-t-cell responses to DNA vaccines Journal of Virology 2002 76:11911-11919 DOI:10.1128/jvi.76.23.11911-11919.2002 PMID:12414933
- Hassett, D. E., Slifka, M. K., Zhang, J., Whitton, J. L. Direct ex vivo kinetic and phenotypic analyses of cd8(+) t-cell responses induced by DNA immunization Journal of Virology 2000 74:8286-8291 DOI:10.1128/jvi.74.18.8286-8291.2000 PMID:10954526
- Hassett, D. E., Zhang, J., Slifka, M., Whitton, J. L. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization Journal of Virology 2000 74:2620-2627 DOI:10.1128/jvi.74.6.2620-2627.2000 PMID:10684276
- Whitton, J. L., Rodriguez, F., Zhang, J., Hassett, D. E. DNA immunization: Mechanistic studies Vaccine 1999 17:1612-1619 DOI:10.1016/s0264-410x(98)00418-6 PMID:10194813
- Hassett, D. E., Zhang, J., Whitton, J. L. Induction of antiviral antibodies by DNA immunization requires neither perforin-mediated nor cd8(+)-t-cell-mediated lysis of antigen-expressing cells Journal of Virology 1999 73:7870-7873 PMID:10438882 PMCID:PMC104319
- Hassett, D. E., Zhang, J., Whitton, J. L. Plasmid DNA vaccines are effective in the absence of ifn gamma Virology 1999 263:175-183 DOI:10.1006/viro.1999.9957 PMID:10544092
- Akwa, Y., Hassett, D. E., Eloranta, M. L., Sandberg, K., Masliah, E., Powell, H., Whitton, J. L., Bloom, F. E., Campbell, I. L. Transgenic expression of ifn-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration Journal of Immunology 1998 161:5016-5026 PMID:9794439
- Yokoyama, M., Hassett, D. E., Zhang, J., Whitton, J. L. DNA immunization can stimulate florid local inflammation, and the antiviral immunity induced varies depending on injection site Vaccine 1997 15:553-560 DOI:10.1016/s0264-410x(97)00213-2 PMID:9160524
- Hassett, D. E., Zhang, J., Whitton, J. L. Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge Journal of Virology 1997 71:7881-7888 PMID:9311877 PMCID:PMC192144
- Hassett, D. E., Whitton, J. L. DNA immunization Trends in Microbiology 1996 4:307-312 DOI:10.1016/0966-842x(96)10048-2 PMID:8856868