recent publications
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academic article
- Wang, C., Wu, H., Evron, T., Vardy, E., Han, G. W., Huang, X. P., Hufeisen, S. J., Mangano, T. J., Urban, D. J., Katritch, V., Cherezov, V., Caron, M. G., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nature Communications 2014 5:4355 DOI:10.1038/ncomms5355 PMID:25008467 PMCID:PMC4198951
- Frankowski, K. J., Hedrick, M. P., Gosalia, P., Li, K. L., Shi, S. H., Whipple, D., Ghosh, P., Prisinzano, T. E., Schoenen, F. J., Su, Y., Vasile, S., Sergienko, E., et al. Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy ACS Chemical Neuroscience 2012 3:221-236 DOI:10.1021/cn200128x PMID:22737280 PMCID:PMC3378255
- Kocerha, J., Faghihi, M. A., Lopez-Toledano, M. A., Huang, J., Ramsey, A. J., Caron, M. G., Sales, N., Willoughby, D., Elmen, J., Hansen, H. F., Orum, H., Kauppinen, S. Microrna-219 modulates nmda receptor-mediated neurobehavioral dysfunction Proceedings of the National Academy of Sciences of the United States of America 2009 106:3507-3512 DOI:10.1073/pnas.0805854106 PMID:19196972 PMCID:PMC2651305
- Medvedev, I. O., Gainetdinov, R. R., Sotnikova, T. D., Bohn, L. M., Caron, M. G., Dykstra, L. A. Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice Psychopharmacology 2005 180:408-413 DOI:10.1007/s00213-005-2173-y PMID:15719221
- Bohn, L. M., Dykstra, L. A., Lefkowitz, R. J., Caron, M. G., Barak, L. S. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery Molecular Pharmacology 2004 66:106-112 DOI:10.1124/mol.66.1.106 PMID:15213301
- Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J., Caron, M. G. Desensitization of G protein-coupled receptors and neuronal functions Annual Review of Neuroscience 2004 27:107-144 DOI:10.1146/annurev.neuro.27.070203.144206 PMID:15217328
- Bohn, L. M., Gainetdinov, R. R., Caron, M. G. G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse - psychostimulant and opiate studies in knockout mice Neuromolecular Medicine 2004 5:41-50 DOI:10.1385/nmm:5:1:041 PMID:15001811
- Johnson, E. C., Bohn, L. M., Barak, L. S., Birse, R. T., Nassel, D. R., Caron, M. G., Taghert, P. H. Identification of drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions Journal of Biological Chemistry 2003 278:52172-52178 DOI:10.1074/jbc.M306756200 PMID:14555656
- Bohn, L. M., Gainetdinov, R. R., Sotnikova, T. D., Medvedev, I. O., Lefkowitz, R. J., Dykstra, L. A., Caron, M. G. Enhanced rewarding properties of morphine, but not cocaine, in beta arrestin-2 knock-out mice Journal of Neuroscience 2003 23:10265-10273 PMID:14614085
- Cyr, M., Beaulieu, J. M., Laakso, A., Sotnikova, T. D., Yao, W. D., Bohn, L. M., Gainetdinov, R. R., Caron, M. G. Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons Proceedings of the National Academy of Sciences of the United States of America 2003 100:11035-11040 DOI:10.1073/pnas.1831768100 PMID:12958210 PMCID:PMC196922
- Gainetdinov, R. R., Bohn, L. M., Sotnikova, T. D., Cyr, M., Laakso, A., Macrae, A. D., Torres, G. E., Kim, K. M., Lefkowitz, R. J., Caron, M. G., Premont, R. T. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice Neuron 2003 38:291-303 DOI:10.1016/s0896-6273(03)00192-2 PMID:12718862
- Bohn, L. M., Lefkowitz, R. J., Caron, M. G. Differential mechanisms of morphine antinociceptive tolerance revealed in beta arrestin-2 knock-out mice Journal of Neuroscience 2002 22:10494-10500 PMID:12451149
- Wilbanks, A. M., Laporte, S. A., Bohn, L. M., Barak, L. S., Caron, M. G. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Biochemistry 2002 41:11981-11989 DOI:10.1021/bi020275m PMID:12356298
- Gainetdinov, R. R., Mohn, A. R., Bohn, L. M., Caron, M. G. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter Proceedings of the National Academy of Sciences of the United States of America 2001 98:11047-11054 DOI:10.1073/pnas.191353298 PMID:11572967 PMCID:PMC58681
- Bohn, L. M., Xu, F., Gainetdinov, R. R., Caron, M. G. Potentiated opioid analgesia in norepinephrine transporter knock-out mice Journal of Neuroscience 2000 20:9040-9045 PMID:11124980
- Bohn, L. M., Gainetdinov, R. R., Lin, F. T., Lefkowitz, R. J., Caron, M. G. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence Nature 2000 408:720-723 PMID:11130073
- Xu, F., Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Bohn, L. M., Miller, G. W., Wang, Y. M., Caron, M. G. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants Nature Neuroscience 2000 3:465-471 PMID:10769386
- Bohn, L. M., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., Lin, F. T. Enhanced morphine analgesia in mice lacking beta-arrestin 2 Science 1999 286:2495-2498 DOI:10.1126/science.286.5449.2495 PMID:10617462
- Gainetdinov, R. R., Bohn, L. M., Walker, J. K. L., Laporte, S. A., Macrae, A. D., Caron, M. G., Lefkowitz, R. J., Premont, R. T. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice Neuron 1999 24:1029-1036 DOI:10.1016/s0896-6273(00)81048-x PMID:10624964
- Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., Lefkowitz, R. J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization Journal of Biological Chemistry 1997 272:25425-25428 DOI:10.1074/jbc.272.41.25425 PMID:9325250