recent publications

• academic article

  • Wang, C., Wu, H., Evron, T., Vardy, E., Han, G. W., Huang, X. P., Hufeisen, S. J., Mangano, T. J., Urban, D. J., Katritch, V., Cherezov, V., Caron, M. G., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nature Communications  2014 5:4355  DOI:10.1038/ncomms5355  PMID:25008467  PMCID:PMC4198951
  • Frankowski, K. J., Hedrick, M. P., Gosalia, P., Li, K. L., Shi, S. H., Whipple, D., Ghosh, P., Prisinzano, T. E., Schoenen, F. J., Su, Y., Vasile, S., Sergienko, E., et al. Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy ACS Chemical Neuroscience  2012 3:221-236  DOI:10.1021/cn200128x  PMID:22737280  PMCID:PMC3378255
  • Kocerha, J., Faghihi, M. A., Lopez-Toledano, M. A., Huang, J., Ramsey, A. J., Caron, M. G., Sales, N., Willoughby, D., Elmen, J., Hansen, H. F., Orum, H., Kauppinen, S. Microrna-219 modulates nmda receptor-mediated neurobehavioral dysfunction Proceedings of the National Academy of Sciences of the United States of America  2009 106:3507-3512  DOI:10.1073/pnas.0805854106  PMID:19196972  PMCID:PMC2651305
  • Medvedev, I. O., Gainetdinov, R. R., Sotnikova, T. D., Bohn, L. M., Caron, M. G., Dykstra, L. A. Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice Psychopharmacology  2005 180:408-413  DOI:10.1007/s00213-005-2173-y  PMID:15719221
  • Gainetdinov, R. R., Premont, R. T., Bohn, L. M., Lefkowitz, R. J., Caron, M. G. Desensitization of G protein-coupled receptors and neuronal functions Annual Review of Neuroscience  2004 27:107-144  DOI:10.1146/annurev.neuro.27.070203.144206  PMID:15217328
  • Bohn, L. M., Gainetdinov, R. R., Caron, M. G. G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse - psychostimulant and opiate studies in knockout mice Neuromolecular Medicine  2004 5:41-50  DOI:10.1385/nmm:5:1:041  PMID:15001811
  • Bohn, L. M., Dykstra, L. A., Lefkowitz, R. J., Caron, M. G., Barak, L. S. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery Molecular Pharmacology  2004 66:106-112  DOI:10.1124/mol.66.1.106  PMID:15213301
  • Gainetdinov, R. R., Bohn, L. M., Sotnikova, T. D., Cyr, M., Laakso, A., Macrae, A. D., Torres, G. E., Kim, K. M., Lefkowitz, R. J., Caron, M. G., Premont, R. T. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice Neuron  2003 38:291-303  DOI:10.1016/s0896-6273(03)00192-2  PMID:12718862
  • Bohn, L. M., Gainetdinov, R. R., Sotnikova, T. D., Medvedev, I. O., Lefkowitz, R. J., Dykstra, L. A., Caron, M. G. Enhanced rewarding properties of morphine, but not cocaine, in beta arrestin-2 knock-out mice Journal of Neuroscience  2003 23:10265-10273  PMID:14614085
  • Johnson, E. C., Bohn, L. M., Barak, L. S., Birse, R. T., Nassel, D. R., Caron, M. G., Taghert, P. H. Identification of drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions Journal of Biological Chemistry  2003 278:52172-52178  DOI:10.1074/jbc.M306756200  PMID:14555656
  • Cyr, M., Beaulieu, J. M., Laakso, A., Sotnikova, T. D., Yao, W. D., Bohn, L. M., Gainetdinov, R. R., Caron, M. G. Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons Proceedings of the National Academy of Sciences of the United States of America  2003 100:11035-11040  DOI:10.1073/pnas.1831768100  PMID:12958210  PMCID:PMC196922
  • Wilbanks, A. M., Laporte, S. A., Bohn, L. M., Barak, L. S., Caron, M. G. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors Biochemistry  2002 41:11981-11989  DOI:10.1021/bi020275m  PMID:12356298
  • Bohn, L. M., Lefkowitz, R. J., Caron, M. G. Differential mechanisms of morphine antinociceptive tolerance revealed in beta arrestin-2 knock-out mice Journal of Neuroscience  2002 22:10494-10500  PMID:12451149
  • Gainetdinov, R. R., Mohn, A. R., Bohn, L. M., Caron, M. G. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter Proceedings of the National Academy of Sciences of the United States of America  2001 98:11047-11054  DOI:10.1073/pnas.191353298  PMID:11572967  PMCID:PMC58681
  • Xu, F., Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Bohn, L. M., Miller, G. W., Wang, Y. M., Caron, M. G. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants Nature Neuroscience  2000 3:465-471  PMID:10769386
  • Bohn, L. M., Gainetdinov, R. R., Lin, F. T., Lefkowitz, R. J., Caron, M. G. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence Nature  2000 408:720-723  PMID:11130073
  • Bohn, L. M., Xu, F., Gainetdinov, R. R., Caron, M. G. Potentiated opioid analgesia in norepinephrine transporter knock-out mice Journal of Neuroscience  2000 20:9040-9045  PMID:11124980
  • Bohn, L. M., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., Lin, F. T. Enhanced morphine analgesia in mice lacking beta-arrestin 2 Science  1999 286:2495-2498  DOI:10.1126/science.286.5449.2495  PMID:10617462
  • Gainetdinov, R. R., Bohn, L. M., Walker, J. K. L., Laporte, S. A., Macrae, A. D., Caron, M. G., Lefkowitz, R. J., Premont, R. T. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice Neuron  1999 24:1029-1036  DOI:10.1016/s0896-6273(00)81048-x  PMID:10624964
  • Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., Lefkowitz, R. J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization Journal of Biological Chemistry  1997 272:25425-25428  DOI:10.1074/jbc.272.41.25425  PMID:9325250