recent publications

• academic article

  • Zhang, F., Yao, J., Ke, J., Zhang, L., Lam, V. Q., Xin, X. F., Zhou, X. E., Chen, J., Brunzelle, J., Griffin, P. R., Zhou, M., Xu, H. E., et al. Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling Nature  2015 525:269-273  DOI:10.1038/nature14661  PMID:26258305  PMCID:PMC4567411
  • Sun, Y., Liu, C. H., SanGiovanni, J. P., Evans, L. P., Tian, K. T., Zhang, B., Stahl, A., Pu, W. T., Kamenecka, T. M., Solt, L. A., Chen, J. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation Proceedings of the National Academy of Sciences of the United States of America  2015 112:10401-10406  DOI:10.1073/pnas.1504387112  PMID:26243880  PMCID:PMC4547221
  • Chang, E. Y., Bae, W. C., Shao, H., Biswas, R., Li, S., Chen, J., Patil, S., Healey, R., D'Lima, D. D., Chung, C. B., Du, J. Ultrashort echo time magnetization transfer (UTE-MT) imaging of cortical bone NMR in Biomedicine  2015 28:873-880  DOI:10.1002/nbm.3316  PMID:25981914  PMCID:PMC4652942
  • Marabini, R., Carragher, B., Chen, S., Chen, J., Cheng, A., Downing, K. H., Frank, J., Grassucci, R. A., Heymann, J. B., Jiang, W., Jonic, S., Liao, H. Y., et al. CTF Challenge: Result summary Journal of Structural Biology  2015 190:348-359  DOI:10.1016/j.jsb.2015.04.003  PMID:25913484  PMCID:PMC4672951
  • Muldoon, P. P., Chen, J., Harenza, J. L., Abdullah, R. A., Sim-Selley, L. J., Cravatt, B. F., Miles, M. F., Chen, X., Lichtman, A. H., Damaj, M. I. Inhibition of monoacylglycerol lipase reduces nicotine withdrawal British Journal of Pharmacology  2015 172:869-882  DOI:10.1111/bph.12948  PMID:25258021  PMCID:PMC4301695
  • Repunte-Canonigo, V., Chen, J., Lefebvre, C., Kawamura, T., Kreifeldt, M., Basson, O., Roberts, A. J., Sanna, P. P. MeCP2 regulates ethanol sensitivity and intake Addiction Biology  2014 19:791-799  DOI:10.1111/adb.12047  PMID:23448145  PMCID:PMC3692583
  • Banerjee, I., Zhang, J., Moore-Morris, T., Pfeiffer, E., Buchholz, K. S., Liu, A., Ouyang, K., Stroud, M. J., Gerace, L., Evans, S. M., McCulloch, A., Chen, J. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response PLoS Genetics  2014 10:e1004114  DOI:10.1371/journal.pgen.1004114  PMID:24586179  PMCID:PMC3930490
  • Brigger, D., Torbett, B. E., Chen, J., Fey, M. F., Tschan, M. P. Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation Biochemical and Biophysical Research Communications  2013 438:283-288  DOI:10.1016/j.bbrc.2013.07.056  PMID:23891751  PMCID:PMC4225710
  • Yuan, J., Mehta, P. P., Yin, M. J., Sun, S. X., Zou, A. H., Chen, J., Rafidi, K., Feng, Z., Nickel, J., Engebretsen, J., Hallin, J., Blasina, A., et al. PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity Molecular Cancer Therapeutics  2011 10:2189-2199  DOI:10.1158/1535-7163.mct-11-0185  PMID:21750219
  • Chen, J., Shi, C. X., Mahoney, E. M., Dunn, E. S., Rinfret, S., Caro, J. J., O'Brien, J., El-Hadi, W., Bhatt, D. L., Topol, E. J., Cohen, D. J. Economic evaluation of clopidogrel plus aspirin for secondary prevention of cardiovascular events in canada for patients with established cardiovascular disease: Results from the charisma trial Canadian Journal of Cardiology  2011 27:222-231  DOI:10.1016/j.cjca.2010.12.021  PMID:21459271
  • Chen, J., Bhatt, D. L., Dunn, E. S., Shi, C. X., Caro, J. J., Mahoney, E. M., Gabriel, S., Jackson, J. D., Topol, E. J., Cohen, D. J. Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone for secondary prevention of cardiovascular events: Results from the charisma trial Value in Health  2009 12:872-879  DOI:10.1111/j.1524-4733.2009.00529.x  PMID:19490556
  • Pawlikowska, L., Hu, D. L., Huntsman, S., Sung, A., Chu, C., Chen, J., Joyner, A. H., Schork, N. J., Hsueh, W. C., Reiner, A. P., Psaty, B. M., Atzmon, G., et al. Association of common genetic variation in the insulin/igf1 signaling pathway with human longevity Aging Cell  2009 8:460-472  DOI:10.1111/j.1474-9726.2009.00493.x  PMID:19489743  PMCID:PMC3652804
  • Haudenschild, D. R., Chen, J., Steklov, N., Lotz, M. K., D'Lima, D. D. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli Molecular & Cellular Biomechanics  2009 6:135-144  PMID:19670824  PMCID:PMC2785729
  • Hallmayer, J., Faraco, J., Lin, L., Hesselson, S., Winkelmann, J., Kawashima, M., Mayer, G., Plazzi, G., Nevsimalova, S., Bourgin, P., Hong, S. S. C., Honda, Y., et al. Narcolepsy is strongly associated with the t-cell receptor alpha locus Nature Genetics  2009 41:708-711  DOI:10.1038/ng.372  PMID:19412176  PMCID:PMC2803042
  • Hu, X. Y., Chung, A. Y., Wu, I., Foldi, J., Chen, J., Ji, J. D., Tateya, T., Kang, Y. J., Han, J. H., Gessler, M., Kageyama, R., Ivashkiv, L. B. Integrated regulation of toll-like receptor responses by notch and interferon-gamma pathways Immunity  2008 29:691-703  DOI:10.1016/j.immuni.2008.08.016  PMID:18976936  PMCID:PMC2585039
  • Haudenschild, D. R., Nguyen, B., Chen, J., D'Lima, D. D., Lotz, M. K. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes Arthritis and Rheumatism  2008 58:2735-2742  DOI:10.1002/art.23797  PMID:18759278  PMCID:PMC2562294
  • Laurent, L. C., Chen, J., Ulitsky, I., Mueller, F. J., Lu, C., Shamir, R., Fan, J. B., Loring, J. F. Comprehensive microrna profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence Stem Cells  2008 26:1506-1516  DOI:10.1634/stemcells.2007-1081  PMID:18403753
  • Zhang, L., Ding, L., Cheung, T. H., Dong, M. Q., Chen, J., Sewell, A. K., Liu, X., Yates, J. R., Han, M. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2 Molecular Cell  2007 28:598-613  DOI:10.1016/j.molcel.2007.09.014  PMID:18042455  PMCID:PMC2186060
  • Cai, J. L., Chen, J., Liu, Y., Miura, T., Luo, Y. Q., Loring, J. F., Freed, W. J., Rao, M. S., Zeng, X. M. Assessing self-renewal and differentiation in human embryonic stem cell lines Stem Cells  2006 24:516-530  DOI:10.1634/stemcells.2005-0143  PMID:16293578  PMCID:PMC1855239
  • Craig, S. L., Lin, S., Chen, J., Rebek, J. An NMR study of the rates of single-molecule exchange in a cylindrical host capsule Journal of the American Chemical Society  2002 124:8780-8781  DOI:10.1021/ja025672z  PMID:12137515
  • Chen, J., Korner, S., Craig, S. L., Lin, S., Rudkevich, D. M., Rebek, J. Chemical amplification with encapsulated reagents Proceedings of the National Academy of Sciences of the United States of America  2002 99:2593-2596  DOI:10.1073/pnas.052706499  PMID:11880614  PMCID:PMC122392
  • Chen, J., Rebek, J. Selectivity in an encapsulated cycloaddition reaction Organic Letters  2002 4:327-329  DOI:10.1021/ol0168115  PMID:11820871
  • Chen, J., Korner, S., Craig, S. L., Rudkevich, D. M., Rebek, J. Chemistry - amplification by compartmentalization Nature  2002 415:385-386  DOI:10.1038/415385b  PMID:11807541
  • Lucking, U., Chen, J., Rudkevich, D. A., Rebek, J. A self-folding metallocavitand Journal of the American Chemical Society  2001 123:9929-9934  DOI:10.1021/ja011488m  PMID:11592871
  • Wu, X., Petrini, J. H., Heine, W. F., Weaver, D. T., Livingston, D. M., Chen, J. Independence of R/M/N focus formation and the presence of intact BRCA1 Science  2000 289:11  DOI:10.1126/science.289.5476.11a  PMID:10928918
  • Pinsky, D. J., Liao, H., Lawson, C. A., Yan, S. F., Chen, J., Carmeliet, P., Loskutoff, D. J., Stern, D. M. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition Journal of Clinical Investigation  1998 102:919-928  DOI:10.1172/jci307  PMID:9727060  PMCID:PMC508957