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The cd40-cd154 system in anti-infective host defense

Academic Article
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Overview

authors

  • Grewal, I. S.
  • Borrow, P.
  • Pamer, E. G.
  • Oldstone, Michael
  • Flavell, R. A.

publication date

  • August 1997

journal

  • Current Opinion in Immunology  Journal

abstract

  • Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.

subject areas

  • Animals
  • Antigen Presentation
  • Antigens, CD40
  • Borrelia Infections
  • Borrelia burgdorferi (UMLS)
  • CD40 Ligand
  • Humans
  • Infection
  • Leishmaniasis
  • Listeriosis
  • Macrophage Activation
  • Membrane Glycoproteins
  • Mice
  • Nematode Infections
  • Pneumocystis Infections
  • T-Lymphocyte Subsets
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Identity

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(97)80100-8

PubMed ID

  • 9287184
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Additional Document Info

start page

  • 491

end page

  • 497

volume

  • 9

issue

  • 4

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