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C-fos deficiency inhibits induction of mrna for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress

Academic Article
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Overview

authors

  • Serova, L. I.
  • Saez, Enrique
  • Spiegelman, B. M.
  • Sabban, E. L.

publication date

  • May 1998

journal

  • Journal of Neurochemistry  Journal

abstract

  • Recent studies indicated that c-Fos protein may be mediating stress-elicited transcriptional activation of genes involved in neurotransmitter biosynthesis. However, direct evidence for c-Fos mediating these changes in gene expression has been lacking. Mice with disrupted c-fos gene (+/- or -/- genotypes) were used to examine the effect of immobilization stress on a group of stress-responsive genes. In male adrenals, c-Fos was found not essential for stress-elicited activation of expression of tyrosine hydroxylase, dopamine beta-hydroxylase (DBH), phenylethanolamine N-methyltransferase, or neuropeptide Y. In females, immobilization failed to induce adrenal DBH in the c-Fos-deficient mice. In brainstem, c-Fos was indispensable for elevation of DBH mRNA in both genders. The gene, gender, and tissue specificity in the requirement for c-Fos points to diversity in adaptation mechanisms to stress.

subject areas

  • Animals
  • Dopamine beta-Hydroxylase
  • Enzyme Induction
  • Enzymes
  • Female
  • Immobilization
  • Male
  • Mice
  • Neuropeptide Y
  • Neurotransmitter Agents
  • Phenylethanolamine N-Methyltransferase
  • Proto-Oncogene Proteins c-fos
  • RNA, Messenger
  • Stress, Physiological
  • Tyrosine 3-Monooxygenase
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Research

keywords

  • c-Fos
  • dopamine beta-hydroxylase
  • gender
  • gene expression
  • immobilization stress
  • neuropeptide Y
  • phenylethanolamine N-methyltransferase
  • tyrosine hydroxylase
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Identity

International Standard Serial Number (ISSN)

  • 0022-3042

PubMed ID

  • 9572277
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Additional Document Info

start page

  • 1935

end page

  • 1940

volume

  • 70

issue

  • 5

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