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Restricted use of T-cell receptor V-genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

Academic Article
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Overview

authors

  • Urban, J. L.
  • Kumar, V.
  • Kono, Dwight
  • Gomez, C.
  • Horvath, S. J.
  • Clayton, J.
  • Ando, D. G.
  • Sercarz, E. E.
  • Hood, L.

publication date

  • August 1988

journal

  • Cell  Journal

abstract

  • Experimental allergic encephalomyelitis (EAE) is a paralytic autoimmune disease induced in susceptible animals by active immunization with myelin basic protein (MBP) or by passive transfer of MBP-specific T helper (TH) lymphocytes. We have analyzed the T cell receptor genes of 33 clonally distinct TH cells specific for a nonapeptide of MBP inducing EAE in B10.PL (H-2u) mice. All 33 TH cells used two alpha variable gene segments (V alpha 2.3, 61%; V alpha 4.2, 39%), the same alpha joining gene segment (J alpha 39), and two V beta and J beta gene segments (V beta 8.2-J beta 2.6, 79%; V beta 13-J beta 2.2, 21%). The anti-V beta 8 monoclonal antibody F23.1 was found to block completely recognition of the nonapeptide by V beta 8 TH cells in vitro and to reduce significantly the susceptibility of B10.PL mice to peptide-induced EAE.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Base Sequence
  • Encephalomyelitis, Autoimmune, Experimental
  • Epitopes
  • Flow Cytometry
  • Hybridomas
  • Immunization
  • Lymph Nodes
  • Mice
  • Molecular Sequence Data
  • Myelin Basic Protein
  • Receptors, Antigen, T-Cell
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(88)90079-7

PubMed ID

  • 2456857
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Additional Document Info

start page

  • 577

end page

  • 592

volume

  • 54

issue

  • 4

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