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Evolutionary analysis of HIV-1 protease inhibitors: methods for design of inhibitors that evade resistance

Academic Article
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Overview

authors

  • Stoffler, D.
  • Sanner, Michel
  • Morris, G. M.
  • Olson, Arthur
  • Goodsell, David

publication date

  • July 2002

journal

  • Proteins-Structure Function and Genetics  Journal

subject areas

  • Acquired Immunodeficiency Syndrome
  • Binding Sites
  • Biological Evolution
  • Computational Biology
  • Computer Simulation
  • Computer-Aided Design
  • Drug Design
  • Drug Resistance, Viral
  • Drug Therapy, Combination
  • HIV Protease
  • HIV Protease Inhibitors
  • HIV-1
  • Humans
  • Indinavir
  • Models, Molecular
  • Mutation
  • Nelfinavir
  • Ritonavir
  • Saquinavir
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Research

keywords

  • AIDS therapy
  • HIV-1 protease
  • coevolution
  • computer-aided drug design
  • drug resistance
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Identity

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/prot.10130

PubMed ID

  • 12012338
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Additional Document Info

start page

  • 63

end page

  • 74

volume

  • 48

issue

  • 1

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