Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Adult mouse brain gene expression patterns bear an embryologic imprint

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Zapala, M. A.
  • Hovatta, I.
  • Ellison, J. A.
  • Wodicka, L.
  • Del Rio, J. A.
  • Tennant, R.
  • Tynan, W.
  • Broide, R. S.
  • Helton, R.
  • Stoveken, B. S.
  • Winrow, C.
  • Lockhart, D. J.
  • Reilly, J. F.
  • Young, W. G.
  • Bloom, Floyd
  • Barlow, C.

publication date

  • July 2005

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural tissues covering the mouse central nervous system and found, surprisingly, that the adult brain bears a transcriptional "imprint" consistent with both embryological origins and classic evolutionary relationships. Embryonic cellular position along the anterior-posterior axis of the neural tube was shown to be closely associated with, and possibly a determinant of, the gene expression patterns in adult structures. We also observed a significant number of embryonic patterning and homeobox genes with region-specific expression in the adult nervous system. The relationships between global expression patterns for different anatomical regions and the nature of the observed region-specific genes suggest that the adult brain retains a degree of overall gene expression established during embryogenesis that is important for regional specificity and the functional relationships between regions in the adult. The complete collection of extensively annotated gene expression data along with data mining and visualization tools have been made available on a publicly accessible web site (www.barlow-lockhart-brainmapnimhgrant.org).

subject areas

  • Algorithms
  • Animals
  • Biological Evolution
  • Central Nervous System
  • Cluster Analysis
  • Databases, Genetic
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Mice
  • Microarray Analysis
  • Models, Neurological
scroll to property group menus

Research

keywords

  • database
  • development
  • evolution
  • gene expression profiling
  • inbred strains of mice
scroll to property group menus

Identity

PubMed Central ID

  • PMC1173363

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0503357102

PubMed ID

  • 16002470
scroll to property group menus

Additional Document Info

start page

  • 10357

end page

  • 10362

volume

  • 102

issue

  • 29

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support