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Learning performance of normal and mutant Drosophila after repeated conditioning trials with discrete stimuli

Academic Article
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Overview

authors

  • Beck, C. D. O.
  • Schroeder, B.
  • Davis, Ronald

publication date

  • April 2000

journal

  • Journal of Neuroscience  Journal

abstract

  • A new olfactory conditioning procedure is described using short training trials with discrete presentation of conditioned stimuli (CS) and unconditioned stimuli (US). A short odor presentation along with a single-shock stimulus produced modest but reliable and reproducible learning. Multiple trials presented sequentially improved performance with increasing trial number. Trial spacing had a significant impact on performance. Two trials presented with a short intertrial interval (ITI) produced no improvement over a single trial; two trials with a 15 min ITI significantly boosted performance. This effect required two associative trials, because substituting one of the trials with the CS alone, US alone, or an unpaired CS-US failed to boost performance. The increase in initial performance with two trials decayed within 15 min after training. Thus, the effect is short-lived. The utility of using a battery of tests, including a single short trial, two massed trials, and two spaced trials, to investigate parameters of memory formation in several mutants was demonstrated.

subject areas

  • Alleles
  • Animals
  • Conditioning, Operant
  • Drosophila
  • Electric Stimulation
  • Learning
  • Memory
  • Mutation
  • Phenotype
  • Smell
  • Time Factors
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Research

keywords

  • Drosophila
  • acquisition
  • learning mutant
  • massed training
  • olfactory conditioning
  • spaced training
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Identity

International Standard Serial Number (ISSN)

  • 0270-6474

PubMed ID

  • 10751447
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Additional Document Info

start page

  • 2944

end page

  • 2953

volume

  • 20

issue

  • 8

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