recent publications
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academic article
- Li, C. L., Piran, S., Chen, P. G., Lang, S., Zarpellon, A., Jin, J. W., Zhu, G. H., Reheman, A., van der Wal, D. E., Simpson, E. K., Ni, R., Gross, P. L. The maternal immune response to fetal platelet GPIb alpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies Journal of Clinical Investigation 2011 121:4537-4547 DOI:10.1172/jci57850 PMID:22019589 PMCID:PMC3204841
- Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J. A., Ware, J., Ruggeri, Z. M., Kunicki, T. J. The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6(-/-) mice Blood 2008 111:1266-1273 DOI:10.1182/blood-2007-09-111369 PMID:17991808 PMCID:PMC2214743
- Jain, S., Zuka, M., Liu, J. L., Russell, S., Dent, J., Guerrero, J. A., Forsyth, J., Maruszak, B., Gartner, T. K., Felding-Habermann, B., Ware, J. Platelet glycoprotein Ib alpha supports experimental lung metastasis Proceedings of the National Academy of Sciences of the United States of America 2007 104:9024-9028 DOI:10.1073/pnas.0700625104 PMID:17494758 PMCID:PMC1885621
- Bergmeier, W., Piffath, C. L., Goerge, T., Cifuni, S. M., Ruggeri, Z. M., Ware, J., Wagner, D. D. The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis Proceedings of the National Academy of Sciences of the United States of America 2006 103:16900-16905 DOI:10.1073/pnas.0608207103 PMID:17075060 PMCID:PMC1636551
- Konstantinides, S., Ware, J., Marchese, P., Almus-Jacobs, F., Loskutoff, D. J., Ruggeri, Z. M. Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis Journal of Thrombosis and Haemostasis 2006 4:2014-2021 DOI:10.1111/j.1538-7836.2006.02086.x PMID:16961609
- Kisucka, J., Butterfield, C. E., Duda, D. G., Eichenberger, S. C., Saffaripour, S., Ware, J., Ruggeri, Z. M., Jain, R. K., Folkman, J., Wagner, D. D. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage Proceedings of the National Academy of Sciences of the United States of America 2006 103:855-860 DOI:10.1073/pnas.0510412103 PMID:16418262 PMCID:PMC1348013
- Federici, A. B., Canciani, M. T., Forza, I., Mannucci, P. M., Marchese, P., Ware, J., Ruggeri, Z. M. A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ib alpha for the diagnosis of patients with low von Willebrand factor levels Haematologica 2004 89:77-85 PMID:14754609
- Furihata, K., Kanaji, S., Kato, K., Kunicki, T. J., Marchese, P., Reininger, A., Ruggeri, Z. M., Russell, S., Ware, J. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Blood 2003 102:1701-1707 DOI:10.1182/blood-2003-03-0717 PMID:12738669
- Celikel, R., McClintock, R. A., Roberts, J. R., Mendolicchio, G. L., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Science 2003 301:218-221 DOI:10.1126/science.1084183 PMID:12855810
- Cattaneo, M., Zighetti, M. L., Lombardi, R., Martinez, C., Lecchi, A., Conley, P. B., Ware, J., Ruggeri, Z. M. Molecular bases of defective signal transduction in the platelet P2Y(12) receptor of a patient with congenital bleeding Proceedings of the National Academy of Sciences of the United States of America 2003 100:1978-1983 DOI:10.1073/pnas.0437879100 PMID:12578987 PMCID:PMC149944
- Kasirer-Friede, A., Ware, J., Leng, L. J., Marchese, P., Ruggeri, Z. M., Stattil, S. J. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha(IIb)beta(3) Journal of Biological Chemistry 2002 277:11949-11956 DOI:10.1074/jbc.M108727200 PMID:11812775
- Ware, J., Ruggeri, Z. M. Platelet adhesion receptors and their participation in hemostasis and thrombosis Drugs of Today 2001 37:265-274 PMID:12768227
- Andre, P., Denis, C. V., Ware, J., Saffaripour, S., Hynes, R. O., Ruggeri, Z. M., Wagner, D. D. Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins Blood 2000 96:3322-3328 PMID:11071623
- Vasudevan, S., Roberts, J. R., McClintock, R. A., Dent, J. A., Celikel, R., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ib alpha Journal of Biological Chemistry 2000 275:12763-12768 DOI:10.1074/jbc.275.17.12763 PMID:10777573
- Ware, J., Russell, S., Ruggeri, Z. M. Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome Proceedings of the National Academy of Sciences of the United States of America 2000 97:2803-2808 DOI:10.1073/pnas.050582097 PMID:10706630 PMCID:PMC16010
- Marchese, P., Saldivar, E., Ware, J., Ruggeri, Z. M. Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field Proceedings of the National Academy of Sciences of the United States of America 1999 96:7837-7842 DOI:10.1073/pnas.96.14.7837 PMID:10393908 PMCID:PMC22148
- Celikel, R., Madhusudan, Varughese, K., Shima, M., Yoshioka, A., Ware, J., Ruggeri, Z. M. Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain Blood Cells Molecules and Diseases 1997 23:123-134 DOI:10.1006/bcmd.1997.0128 PMID:9215757
- Federici, A. B., Mannucci, P. M., Stabile, F., Canciani, M. T., DiRocco, N., Miyata, S., Ware, J., Ruggeri, Z. M. A type 2b von Willebrand disease mutation (Ile546 -> Val) associated with an unusual phenotype Thrombosis and Haemostasis 1997 78:1132-1137 PMID:9308766
- Ware, J., Russell, S., Ruggeri, Z. M. Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion Blood Cells Molecules and Diseases 1997 23:292-301 DOI:10.1006/bcmd.1997.0146 PMID:9410473
- Topol, E. J., Califf, R., Granger, C., VandeWerf, F., Aylward, P., Simes, J., Col, J., Armstrong, P., Vahanian, A., Neuhaus, K., Rutsch, W., Ardissino, D., et al. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes New England Journal of Medicine 1996 335:775-782 DOI:10.1056/NEJM199609123351103 PMID:8778585
- Schneppenheim, R., Brassard, J., Krey, S., Budde, U., Kunicki, T. J., Holmberg, L., Ware, J., Ruggeri, Z. M. Defective dimerization of von Willebrand factor subunits due to a Cys -> Arg mutation in type IID von Willebrand disease Proceedings of the National Academy of Sciences of the United States of America 1996 93:3581-3586 DOI:10.1073/pnas.93.8.3581 PMID:8622978 PMCID:PMC39653
- Miyata, S., Goto, S., Federici, A. B., Ware, J., Ruggeri, Z. M. Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibα Journal of Biological Chemistry 1996 271:9046-9053 PMID:8621553
- Marchese, P., Murata, M., Mazzucato, M., Pradella, P., Demarco, L., Ware, J., Ruggeri, Z. M. Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding Journal of Biological Chemistry 1995 270:9571-9578 PMID:7721887
- Ware, J., Russell, S. R., Marchese, P., Murata, M., Mazzucato, M., Demarco, L., Ruggeri, Z. M. Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome Journal of Clinical Investigation 1993 92:1213-1220 DOI:10.1172/jci116692 PMID:7690774 PMCID:PMC288260
- Holmberg, L., Dent, J. A., Schneppenheim, R., Budde, U., Ware, J., Ruggeri, Z. M. von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure Journal of Clinical Investigation 1993 91:2169-2177 DOI:10.1172/jci116443 PMID:8486782 PMCID:PMC288219
- Ware, J., Russell, S. R., Marchese, P., Ruggeri, Z. M. Expression of human platelet glycoprotein Ib alpha in transgenic mice Journal of Biological Chemistry 1993 268:8376-8382 PMID:8463345
- Azuma, H., Hayashi, T., Dent, J. A., Ruggeri, Z. M., Ware, J. Disulfide bond requirements for assembly of the platelet glycoprotein Ib-binding domain of von Willebrand factor Journal of Biological Chemistry 1993 268:2821-2827 PMID:7679102
- Ruggeri, Z. M., Ware, J. von Willebrand factor FASEB Journal 1993 7:308-316 PMID:8440408
- Azuma, H., Sugimoto, M., Ruggeri, Z. M., Ware, J. A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Thrombosis and Haemostasis 1993 69:192-196 PMID:8456433
- Murata, M., Russell, S. R., Ruggeri, Z. M., Ware, J. Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment Journal of Clinical Investigation 1993 91:2133-2137 DOI:10.1172/jci116438 PMID:8486780 PMCID:PMC288214
- Murata, M., Furihata, K., Ishida, F., Russell, S. R., Ware, J., Ruggeri, Z. M. Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness Blood 1992 79:3086-3090 PMID:1586750
- Ruggeri, Z. M., Ware, J. The structure and function of von Willebrand factor Thrombosis and Haemostasis 1992 67:594-599 PMID:1509397
- Azuma, H., Dent, J. A., Sugimoto, M., Ruggeri, Z. M., Ware, J. Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site Journal of Biological Chemistry 1991 266:12342-12347 PMID:1905720
- Ware, J., Dent, J. A., Azuma, H., Sugimoto, M., Kyrle, P. A., Yoshioka, A., Ruggeri, Z. M. Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor Proceedings of the National Academy of Sciences of the United States of America 1991 88:2946-2950 DOI:10.1073/pnas.88.7.2946 PMID:2011604 PMCID:PMC51357
- Murata, M., Ware, J., Ruggeri, Z. M. Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding Journal of Biological Chemistry 1991 266:15474-15480 PMID:1651333
- Ware, J., Russell, S. R., Vicente, V., Scharf, R. E., Tomer, A., McMillan, R., Ruggeri, Z. M. Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome Proceedings of the National Academy of Sciences of the United States of America 1990 87:2026-2030 DOI:10.1073/pnas.87.5.2026 PMID:2308962 PMCID:PMC53618
- Dent, J. A., Berkowitz, S. D., Ware, J., Kasper, C. K., Ruggeri, Z. M. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor Proceedings of the National Academy of Sciences of the United States of America 1990 87:6306-6310 DOI:10.1073/pnas.87.16.6306 PMID:2385594 PMCID:PMC54522