recent publications

• academic article

  • Li, C. L., Piran, S., Chen, P. G., Lang, S., Zarpellon, A., Jin, J. W., Zhu, G. H., Reheman, A., van der Wal, D. E., Simpson, E. K., Ni, R., Gross, P. L. The maternal immune response to fetal platelet GPIb alpha causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies Journal of Clinical Investigation  2011 121:4537-4547  DOI:10.1172/jci57850  PMID:22019589  PMCID:PMC3204841
  • Cheli, Y., Jensen, D., Marchese, P., Habart, D., Wiltshire, T., Cooke, M., Fernandez, J. A., Ware, J., Ruggeri, Z. M., Kunicki, T. J. The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6(-/-) mice Blood  2008 111:1266-1273  DOI:10.1182/blood-2007-09-111369  PMID:17991808  PMCID:PMC2214743
  • Jain, S., Zuka, M., Liu, J. L., Russell, S., Dent, J., Guerrero, J. A., Forsyth, J., Maruszak, B., Gartner, T. K., Felding-Habermann, B., Ware, J. Platelet glycoprotein Ib alpha supports experimental lung metastasis Proceedings of the National Academy of Sciences of the United States of America  2007 104:9024-9028  DOI:10.1073/pnas.0700625104  PMID:17494758  PMCID:PMC1885621
  • Bergmeier, W., Piffath, C. L., Goerge, T., Cifuni, S. M., Ruggeri, Z. M., Ware, J., Wagner, D. D. The role of platelet adhesion receptor GPIb alpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis Proceedings of the National Academy of Sciences of the United States of America  2006 103:16900-16905  DOI:10.1073/pnas.0608207103  PMID:17075060  PMCID:PMC1636551
  • Konstantinides, S., Ware, J., Marchese, P., Almus-Jacobs, F., Loskutoff, D. J., Ruggeri, Z. M. Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis Journal of Thrombosis and Haemostasis  2006 4:2014-2021  DOI:10.1111/j.1538-7836.2006.02086.x  PMID:16961609
  • Kisucka, J., Butterfield, C. E., Duda, D. G., Eichenberger, S. C., Saffaripour, S., Ware, J., Ruggeri, Z. M., Jain, R. K., Folkman, J., Wagner, D. D. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage Proceedings of the National Academy of Sciences of the United States of America  2006 103:855-860  DOI:10.1073/pnas.0510412103  PMID:16418262  PMCID:PMC1348013
  • Federici, A. B., Canciani, M. T., Forza, I., Mannucci, P. M., Marchese, P., Ware, J., Ruggeri, Z. M. A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ib alpha for the diagnosis of patients with low von Willebrand factor levels Haematologica  2004 89:77-85  PMID:14754609
  • Furihata, K., Kanaji, S., Kato, K., Kunicki, T. J., Marchese, P., Reininger, A., Ruggeri, Z. M., Russell, S., Ware, J. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion Blood  2003 102:1701-1707  DOI:10.1182/blood-2003-03-0717  PMID:12738669
  • Celikel, R., McClintock, R. A., Roberts, J. R., Mendolicchio, G. L., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ib-alpha Science  2003 301:218-221  DOI:10.1126/science.1084183  PMID:12855810
  • Cattaneo, M., Zighetti, M. L., Lombardi, R., Martinez, C., Lecchi, A., Conley, P. B., Ware, J., Ruggeri, Z. M. Molecular bases of defective signal transduction in the platelet P2Y(12) receptor of a patient with congenital bleeding Proceedings of the National Academy of Sciences of the United States of America  2003 100:1978-1983  DOI:10.1073/pnas.0437879100  PMID:12578987  PMCID:PMC149944
  • Kasirer-Friede, A., Ware, J., Leng, L. J., Marchese, P., Ruggeri, Z. M., Stattil, S. J. Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha(IIb)beta(3) Journal of Biological Chemistry  2002 277:11949-11956  DOI:10.1074/jbc.M108727200  PMID:11812775
  • Ware, J., Ruggeri, Z. M. Platelet adhesion receptors and their participation in hemostasis and thrombosis Drugs of Today  2001 37:265-274  PMID:12768227
  • Andre, P., Denis, C. V., Ware, J., Saffaripour, S., Hynes, R. O., Ruggeri, Z. M., Wagner, D. D. Platelets adhere to and translocate on von Willebrand factor presented by endothelium in simulated veins Blood  2000 96:3322-3328  PMID:11071623
  • Vasudevan, S., Roberts, J. R., McClintock, R. A., Dent, J. A., Celikel, R., Ware, J., Varughese, K. I., Ruggeri, Z. M. Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ib alpha Journal of Biological Chemistry  2000 275:12763-12768  DOI:10.1074/jbc.275.17.12763  PMID:10777573
  • Ware, J., Russell, S., Ruggeri, Z. M. Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome Proceedings of the National Academy of Sciences of the United States of America  2000 97:2803-2808  DOI:10.1073/pnas.050582097  PMID:10706630  PMCID:PMC16010
  • Marchese, P., Saldivar, E., Ware, J., Ruggeri, Z. M. Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ib alpha in a flow field Proceedings of the National Academy of Sciences of the United States of America  1999 96:7837-7842  DOI:10.1073/pnas.96.14.7837  PMID:10393908  PMCID:PMC22148
  • Celikel, R., Madhusudan, Varughese, K., Shima, M., Yoshioka, A., Ware, J., Ruggeri, Z. M. Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain Blood Cells Molecules and Diseases  1997 23:123-134  DOI:10.1006/bcmd.1997.0128  PMID:9215757
  • Federici, A. B., Mannucci, P. M., Stabile, F., Canciani, M. T., DiRocco, N., Miyata, S., Ware, J., Ruggeri, Z. M. A type 2b von Willebrand disease mutation (Ile546 -> Val) associated with an unusual phenotype Thrombosis and Haemostasis  1997 78:1132-1137  PMID:9308766
  • Ware, J., Russell, S., Ruggeri, Z. M. Cloning of the murine platelet glycoprotein Ib alpha gene highlighting species-specific platelet adhesion Blood Cells Molecules and Diseases  1997 23:292-301  DOI:10.1006/bcmd.1997.0146  PMID:9410473
  • Topol, E. J., Califf, R., Granger, C., VandeWerf, F., Aylward, P., Simes, J., Col, J., Armstrong, P., Vahanian, A., Neuhaus, K., Rutsch, W., Ardissino, D., et al. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes New England Journal of Medicine  1996 335:775-782  DOI:10.1056/NEJM199609123351103  PMID:8778585
  • Schneppenheim, R., Brassard, J., Krey, S., Budde, U., Kunicki, T. J., Holmberg, L., Ware, J., Ruggeri, Z. M. Defective dimerization of von Willebrand factor subunits due to a Cys -> Arg mutation in type IID von Willebrand disease Proceedings of the National Academy of Sciences of the United States of America  1996 93:3581-3586  DOI:10.1073/pnas.93.8.3581  PMID:8622978  PMCID:PMC39653
  • Miyata, S., Goto, S., Federici, A. B., Ware, J., Ruggeri, Z. M. Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibα Journal of Biological Chemistry  1996 271:9046-9053  PMID:8621553
  • Marchese, P., Murata, M., Mazzucato, M., Pradella, P., Demarco, L., Ware, J., Ruggeri, Z. M. Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding Journal of Biological Chemistry  1995 270:9571-9578  PMID:7721887
  • Ware, J., Russell, S. R., Marchese, P., Murata, M., Mazzucato, M., Demarco, L., Ruggeri, Z. M. Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome Journal of Clinical Investigation  1993 92:1213-1220  DOI:10.1172/jci116692  PMID:7690774  PMCID:PMC288260
  • Holmberg, L., Dent, J. A., Schneppenheim, R., Budde, U., Ware, J., Ruggeri, Z. M. von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure Journal of Clinical Investigation  1993 91:2169-2177  DOI:10.1172/jci116443  PMID:8486782  PMCID:PMC288219
  • Ware, J., Russell, S. R., Marchese, P., Ruggeri, Z. M. Expression of human platelet glycoprotein Ib alpha in transgenic mice Journal of Biological Chemistry  1993 268:8376-8382  PMID:8463345
  • Azuma, H., Hayashi, T., Dent, J. A., Ruggeri, Z. M., Ware, J. Disulfide bond requirements for assembly of the platelet glycoprotein Ib-binding domain of von Willebrand factor Journal of Biological Chemistry  1993 268:2821-2827  PMID:7679102
  • Ruggeri, Z. M., Ware, J. von Willebrand factor FASEB Journal  1993 7:308-316  PMID:8440408
  • Azuma, H., Sugimoto, M., Ruggeri, Z. M., Ware, J. A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib Thrombosis and Haemostasis  1993 69:192-196  PMID:8456433
  • Murata, M., Russell, S. R., Ruggeri, Z. M., Ware, J. Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment Journal of Clinical Investigation  1993 91:2133-2137  DOI:10.1172/jci116438  PMID:8486780  PMCID:PMC288214
  • Murata, M., Furihata, K., Ishida, F., Russell, S. R., Ware, J., Ruggeri, Z. M. Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness Blood  1992 79:3086-3090  PMID:1586750
  • Ruggeri, Z. M., Ware, J. The structure and function of von Willebrand factor Thrombosis and Haemostasis  1992 67:594-599  PMID:1509397
  • Azuma, H., Dent, J. A., Sugimoto, M., Ruggeri, Z. M., Ware, J. Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site Journal of Biological Chemistry  1991 266:12342-12347  PMID:1905720
  • Ware, J., Dent, J. A., Azuma, H., Sugimoto, M., Kyrle, P. A., Yoshioka, A., Ruggeri, Z. M. Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor Proceedings of the National Academy of Sciences of the United States of America  1991 88:2946-2950  DOI:10.1073/pnas.88.7.2946  PMID:2011604  PMCID:PMC51357
  • Murata, M., Ware, J., Ruggeri, Z. M. Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding Journal of Biological Chemistry  1991 266:15474-15480  PMID:1651333
  • Ware, J., Russell, S. R., Vicente, V., Scharf, R. E., Tomer, A., McMillan, R., Ruggeri, Z. M. Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome Proceedings of the National Academy of Sciences of the United States of America  1990 87:2026-2030  DOI:10.1073/pnas.87.5.2026  PMID:2308962  PMCID:PMC53618
  • Dent, J. A., Berkowitz, S. D., Ware, J., Kasper, C. K., Ruggeri, Z. M. Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor Proceedings of the National Academy of Sciences of the United States of America  1990 87:6306-6310  DOI:10.1073/pnas.87.16.6306  PMID:2385594  PMCID:PMC54522