Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian-sarcoma viruses

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Antler, A. M.
  • Greenberg, M. E.
  • Edelman, Gerald
  • Hanafusa, H.

publication date

  • 1985

journal

  • Molecular and Cellular Biology  Journal

abstract

  • The level of phosphotyrosine in vinculin was determined in chicken embryo fibroblasts transformed by various strains of avian sarcoma virus. As previously reported (Sefton et al., Cell 24:165-174, 1981), vinculin was phosphorylated at tyrosine residues in most cultures examined, but the level varied greatly and no detectable change was found in cultures infected with Fujinami sarcoma virus or UR2 sarcoma virus. Regardless of the level of vinculin phosphorylation, the number of organized microfilament bundles was found to be decreased in all transformed cells. These results strongly suggest that tyrosine phosphorylation of vinculin is not an obligatory step in cell transformation by this class of oncogenes, nor is it correlated with the associated cytoskeletal disarray.

subject areas

  • Animals
  • Avian Sarcoma Viruses
  • Cell Transformation, Viral
  • Cells, Cultured
  • Chick Embryo
  • Cytoskeleton
  • Muscle Proteins
  • Phosphorylation
  • Phosphotyrosine
  • Tyrosine
  • Vinculin
scroll to property group menus

Identity

PubMed Central ID

  • PMC366703

International Standard Serial Number (ISSN)

  • 0270-7306

PubMed ID

  • 2580230
scroll to property group menus

Additional Document Info

start page

  • 263

end page

  • 267

volume

  • 5

issue

  • 1

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support