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Insulin-like growth factor-i: Compartmentalization within the somatotropic axis?

Academic Article
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Overview

authors

  • Butler, Andrew
  • Yakar, S.
  • LeRoith, D.

publication date

  • April 2002

journal

  • News in Physiological Sciences  Journal

abstract

  • Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.

subject areas

  • Animals
  • Growth
  • Growth Disorders
  • Humans
  • Insulin-Like Growth Factor I
  • Liver
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Identity

International Standard Serial Number (ISSN)

  • 0886-1714

Digital Object Identifier (DOI)

  • 10.1152/nips.01351.2001

PubMed ID

  • 11909998
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Additional Document Info

start page

  • 82

end page

  • 85

volume

  • 17

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