recent publications

• academic article

  • Minnihan, E. C., Ando, N., Brignole, E. J., Olshansky, L., Chittuluru, J., Asturias, F. J., Drennan, C. L., Nocera, D. G., Stubbe, J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase Proceedings of the National Academy of Sciences of the United States of America  2013 110:3835-3840  DOI:10.1073/pnas.1220691110  PMID:23431160  PMCID:PMC3593893
  • Aye, Y., Brignole, E. J., Long, M. J. C., Chittuluru, J., Drennan, C. L., Asturias, F. J., Stubbe, J. Clofarabine targets the large subunit (alpha) of human ribonucleotide reductase in live cells by assembly into persistent hexamers Chemistry & Biology  2012 19:799-805  DOI:10.1016/j.chembiol.2012.05.015  PMID:22840768  PMCID:PMC3408589
  • Zimanyi, C. M., Ando, N., Brignole, E. J., Asturias, F. J., Stubbe, J., Drennan, C. L. Tangled up in knots: structures of inactivated forms of E. Coli class Ia ribonucleotide reductase Structure  2012 20:1374-1383  DOI:10.1016/j.str.2012.05.009  PMID:22727814  PMCID:PMC3459064
  • Minnihan, E. C., Young, D. D., Schultz, P. G., Stubbe, J. Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase Journal of the American Chemical Society  2011 133:15942-15945  DOI:10.1021/ja207719f  PMID:21913683  PMCID:PMC3188361
  • Ando, N., Brignole, E. J., Zimanyi, C. M., Funk, M. A., Yokoyama, K., Asturias, F. J., Stubbe, J., Drennan, C. L. Structural interconversions modulate activity of escherichia coli ribonucleotide reductase Proceedings of the National Academy of Sciences of the United States of America  2011 108:21046-21051  DOI:10.1073/pnas.1112715108  PMID:22160671  PMCID:PMC3248520
  • Marletta, M. A., Stubbe, J. Catalysis and regulation. Editorial overview Current Opinion in Structural Biology  2008 18:641-643  DOI:10.1016/j.sbi.2008.11.006  PMID:19059103
  • Seyedsayamdost, M. R., Xie, J., Chan, C. T. Y., Schultz, P. G., Stubbe, J. Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y(730) and Y(731) in radical propagation Journal of the American Chemical Society  2007 129:15060-15071  DOI:10.1021/ja076043y  PMID:17990884
  • Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Kozarich, J. W., Stubbe, J. Assessment of the role of the bleomycin A(2) pyrimidoblamic acid C4 amino group Journal of the American Chemical Society  1998 120:53-65  DOI:10.1021/ja971889v
  • Tong, W., Burdi, D., Riggs-Gelasco, P., Chen, S., Edmondson, D., Huynh, B. H., Stubbe, J., Han, S., Arvai, A., Tainer, J. Characterization of y122f r2 of escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and x-ray crystallography Biochemistry  1998 37:5840-5848  DOI:10.1021/bi9728811  PMID:9558317
  • Boger, D. L., Ramsey, T. M., Cai, H., Hoehn, S. T., Stubbe, J. Definition of the effect and role of the bleomycin A(2) valerate substituents: preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage Journal of the American Chemical Society  1998 120:9149-9158  DOI:10.1021/ja9816640
  • Wu, W., Vanderwall, D. E., Teramoto, S., Lui, S. M., Hoehn, S. T., Tang, X. J., Turner, C. J., Boger, D. L., Kozarich, J. W., Stubbe, J. NMR studies of Co.deglycoBleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society  1998 120:2239-2250  DOI:10.1021/ja972125i