Dibutyryl-camp induces snap-25 translocation into the neurites in pc12

Academic Article

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Overview

authors

• Sanna, Pietro
• Bloom, Floyd
• Wilson, M. C.

publication date

• March 1991

journal

• Developmental Brain Research  Journal

abstract

• SNAP-25 immunoreactivity was translocated into the endings of the processes induced in PC12 cells by dibutyryl-cAMP-treatment. Conversely, the protein was not present in the endings of the processes seen after NGF-treatment unless dibutyryl-cAMP was used simultaneously. This redistribution of SNAP-25 immunoreactivity appeared to be dependent upon new protein synthesis. Finally, dibutyryl-cAMP was capable of inducing SNAP-25 expression.

subject areas

• Adrenal Gland Neoplasms
• Animals
• Axons
• Bucladesine
• Cell Differentiation
• Cell Line
• Membrane Proteins
• Nerve Growth Factors
• Nerve Tissue Proteins
• Pheochromocytoma
• Synaptosomal-Associated Protein 25

Research

keywords

• CYCLOHEXIMIDE
• DIBUTYRYL-CAMP
• NERVE GROWTH FACTOR
• NEURITE
• PC12
• SNAP-25
• SYNAPTOGENESIS

Identity

International Standard Serial Number (ISSN)

• 0165-3806

Digital Object Identifier (DOI)

• 10.1016/0165-3806(91)90035-h

PubMed ID

• 1645626

Additional Document Info

start page

• 104

end page

• 108

volume

• 59

issue

• 1