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Dibutyryl-camp induces snap-25 translocation into the neurites in pc12

Academic Article
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Overview

authors

  • Sanna, Pietro
  • Bloom, Floyd
  • Wilson, M. C.

publication date

  • March 1991

journal

  • Developmental Brain Research  Journal

abstract

  • SNAP-25 immunoreactivity was translocated into the endings of the processes induced in PC12 cells by dibutyryl-cAMP-treatment. Conversely, the protein was not present in the endings of the processes seen after NGF-treatment unless dibutyryl-cAMP was used simultaneously. This redistribution of SNAP-25 immunoreactivity appeared to be dependent upon new protein synthesis. Finally, dibutyryl-cAMP was capable of inducing SNAP-25 expression.

subject areas

  • Adrenal Gland Neoplasms
  • Animals
  • Axons
  • Bucladesine
  • Cell Differentiation
  • Cell Line
  • Membrane Proteins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Pheochromocytoma
  • Synaptosomal-Associated Protein 25
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Research

keywords

  • CYCLOHEXIMIDE
  • DIBUTYRYL-CAMP
  • NERVE GROWTH FACTOR
  • NEURITE
  • PC12
  • SNAP-25
  • SYNAPTOGENESIS
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Identity

International Standard Serial Number (ISSN)

  • 0165-3806

Digital Object Identifier (DOI)

  • 10.1016/0165-3806(91)90035-h

PubMed ID

  • 1645626
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Additional Document Info

start page

  • 104

end page

  • 108

volume

  • 59

issue

  • 1

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