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Sigma-1 receptor knockout mice display a depressive-like phenotype

Academic Article
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Overview

authors

  • Sabino, V.
  • Cottone, P.
  • Parylak, S. L.
  • Steardo, L.
  • Zorrilla, Eric

publication date

  • March 2009

journal

  • Behavioural Brain Research  Journal

abstract

  • Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior.

subject areas

  • Animals
  • Anxiety
  • Depression
  • Exploratory Behavior
  • Genotype
  • Immobilization
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Mutation
  • Phenotype
  • Polymerase Chain Reaction
  • Receptors, sigma
  • Swimming
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Research

keywords

  • Antidepressant
  • Forced swim
  • Neurosteroids
  • Sigma-1
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Identity

PubMed Central ID

  • PMC2667953

International Standard Serial Number (ISSN)

  • 0166-4328

Digital Object Identifier (DOI)

  • 10.1016/j.bbr.2008.11.036

PubMed ID

  • 19100292
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Additional Document Info

start page

  • 472

end page

  • 476

volume

  • 198

issue

  • 2

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