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Catalytic antibodies

Academic Article
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Overview

authors

  • Tramontano, A.
  • Janda, Kim
  • Lerner, Richard

publication date

  • 1986

journal

  • Science  Journal

abstract

  • Monoclonal antibodies elicited to haptens that are analogs of the transition state for hydrolysis of carboxylic esters behaved as enzymic catalysts with the appropriate substrates. These substrates are distinguished by the structural congruence of both hydrolysis products with haptenic fragments. The haptens were potent inhibitors of this esterolytic activity, in agreement with their classification as transition state analogs. Mechanisms are proposed to account for the different chemical behavior of these antibodies with two types of ester substrates. The generation of an artificial enzyme through transition state stabilization by antibodies was thus demonstrated. These studies indicate a potentially general approach to catalyst design.

subject areas

  • Antibodies, Monoclonal
  • Binding Sites
  • Carboxylic Ester Hydrolases
  • Catalysis
  • Chemical Phenomena
  • Chemistry
  • Esters
  • Haptens
  • Hydrolysis
  • Kinetics
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3787261

PubMed ID

  • 3787261
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Additional Document Info

start page

  • 1566

end page

  • 1570

volume

  • 234

issue

  • 4783

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