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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

Academic Article
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Overview

authors

  • Derijard, B.
  • Raingeaud, J.
  • Barrett, T.
  • Wu, I. H.
  • Han, Jiahuai
  • Ulevitch, Richard
  • Davis, R. J.

publication date

  • 1995

journal

  • Science  Journal

abstract

  • Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK. These data demonstrate that the activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cell Line
  • Cloning, Molecular
  • Enzyme Activation
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 3
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase Kinases
  • Mitogen-Activated Protein Kinases
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Serine-Threonine Kinases
  • Protein-Tyrosine Kinases
  • Signal Transduction
  • Substrate Specificity
  • Transfection
  • p38 Mitogen-Activated Protein Kinases
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7839144

PubMed ID

  • 7839144
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Additional Document Info

start page

  • 682

end page

  • 685

volume

  • 267

issue

  • 5198

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