Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Self-stimulation at lateral hypothalamus and locus coeruleus after specific unilateral lesions of dopamine system

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Koob, George
  • Fray, P. J.
  • Iversen, S. D.

publication date

  • 1978

journal

  • Brain Research  Journal

abstract

  • A group of rats was trained to press levers for electrical stimulation from bipolar electrodes aimed at the lateral hypothalamus (LH), and another group was trained to self-stimulate from electrodes in the locus coeruleus (LC). All rats in both groups were subjected to unilateral injections of 6-hydroxydopamine into the substantia nigra and midbrain ventral tegmentum. The lesions produced profound depletions of dopamine from the ipsilateral frontal cortex, nucleus accumbens/olfactory tubercle, and corpus striatum. Pretreatment with desmethylimipramine prevented loss of noradrenaline in excess of that caused by electrode implantation. The destruction of the dopamine projections produced a persistent and pronounced deficit in intracranial self-stimulation from ipsilateral electrodes in both the LH and LC groups, but only transient effects on self-stimulation from contralateral electrodes at these sites. These results suggest that an intact dopamine system is required for the expression of self-stimulation behaviour.

subject areas

  • Animals
  • Corpus Striatum
  • Dopamine
  • Frontal Lobe
  • Hydroxydopamines
  • Hypothalamus
  • Locus Coeruleus
  • Male
  • Norepinephrine
  • Nucleus Accumbens
  • Olfactory Bulb
  • Rats
  • Receptors, Dopamine
  • Self Stimulation
  • Substantia Nigra
  • Tegmentum Mesencephali
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(78)90222-6

PubMed ID

  • 647383
scroll to property group menus

Additional Document Info

start page

  • 123

end page

  • 140

volume

  • 146

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support