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Lateral diffusion of surface molecules in animal-cells and tissues

Academic Article
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Overview

authors

  • Gall, W. E.
  • Edelman, Gerald

publication date

  • 1981

journal

  • Science  Journal

abstract

  • When bound to cell surfaces, certain lectins such as concanavalin A induce a drop in the average diffusion coefficients (D) of a number of cell surface molecules. To find whether such anchorage modulation occurs naturally, D of surface antigens on different cell and tissue types were measured by fluorescence photobleaching recovery. Values for cells of the same tissue origin under different conditions of growth and association - in tissues, in small aggregates, and as isolated cells - varied by less than twofold when polyspecific monovalent antibodies to cell surface antigens were used, a range much less than the sixfold decrease in D observed after lectin-induced anchorage modulation. Thus, if reversible modulation of the diffusion rate is used naturally as a means of cell signaling, it must involve only a few kinds of surface receptors not detected by the antibodies used in this study. In certain tissues, however, a significant proportion of cells showed no apparent receptor mobility. This "all or none" modulation of lateral diffusion may reflect relatively long-lasting alterations in the states of a single cell type or differentiation among the cells of the particular tissue.

subject areas

  • Animals
  • Antigens, Surface
  • Cell Adhesion
  • Cell Division
  • Cells, Cultured
  • Chick Embryo
  • Cytoskeleton
  • Diffusion
  • Membrane Fluidity
  • Mice
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7196087

PubMed ID

  • 7196087
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Additional Document Info

start page

  • 903

end page

  • 905

volume

  • 213

issue

  • 4510

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