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Neural cell-adhesion molecule mediates initial interactions between spinal-cord neurons and muscle-cells in culture

Academic Article
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Overview

authors

  • Rutishauser, U.
  • Grumet, M.
  • Edelman, Gerald

publication date

  • 1983

journal

  • Journal of Cell Biology  Journal

abstract

  • Previous studies in this laboratory have described a cell surface glycoprotein, called neural cell adhesion molecule or N-CAM, that appears to be a ligand in the adhesion between neural membranes. N-CAM antigenic determinants were also shown to be present on embryonic muscle and an N-CAM-dependent adhesion was demonstrated between retinal cell membranes and muscle cells in short-term assays. The present studies indicate that these antigenic determinants are associated with the N-CAM polypeptide, and that rapid adhesion mediated by this molecule occurs between spinal cord membranes and muscle cells. Detailed examination of the effects of anti-(N-CAM) Fab' fragments in cultures of spinal cord with skeletal muscle showed that the Fab' fragments specifically block adhesion of spinal cord neurites and cells to myotubes. The Fab' did not affect binding of neurites to fibroblasts and collagen substrate, and did not alter myotube morphology. These results indicate that N-CAM adhesion is essential for the in vitro establishment of physical associations between nerve and muscle, and suggest that binding involving N-CAM may be an important early step in synaptogenesis.

subject areas

  • Animals
  • Antigens
  • Axons
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Cell Communication
  • Cell Membrane
  • Cells, Cultured
  • Chick Embryo
  • Muscles
  • Neurons
  • Spinal Cord
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Identity

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.97.1.145

PubMed ID

  • 6863388
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Additional Document Info

start page

  • 145

end page

  • 152

volume

  • 97

issue

  • 1

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