Cascade reactions in total synthesis

Academic Article

• Overview
• Research
• Identity
• Additional Document Info
• View All

Overview

authors

• Nicolaou, K.C.
• Edmonds, D. J.
• Bulger, P. G.

publication date

• 2006

journal

• Angewandte Chemie-International Edition  Journal

abstract

• The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

subject areas

• Biological Products
• Catalysis
• Cyclization
• Molecular Structure
• Stereoisomerism
• Transition Elements

Research

keywords

• cascade reactions
• domino reactions
• natural products
• tandem reactions
• total synthesis

Identity

International Standard Serial Number (ISSN)

• 1433-7851

Digital Object Identifier (DOI)

• 10.1002/anie.200601872

PubMed ID

• 17075967

Additional Document Info

start page

• 7134

end page

• 7186

volume

• 45

issue

• 43