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Genome-wide gene expression profiles of the developing mouse hippocampus

Academic Article
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Overview

authors

  • Mody, M.
  • Cao, Y. X.
  • Cui, Z. Z.
  • Tay, K. Y.
  • Shyong, A.
  • Shimizu, E.
  • Pham, K.
  • Schultz, Peter
  • Welsh, D.
  • Tsien, J. Z.

publication date

  • July 2001

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.

subject areas

  • Animals
  • Animals, Newborn
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Hippocampus
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Transcription, Genetic
  • Up-Regulation
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Identity

PubMed Central ID

  • PMC37526

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.141244998

PubMed ID

  • 11438693
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Additional Document Info

start page

  • 8862

end page

  • 8867

volume

  • 98

issue

  • 15

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