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Coupling of folding and binding for unstructured proteins

Academic Article
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Overview

authors

  • Dyson, Jane
  • Wright, Peter

publication date

  • February 2002

journal

  • Current Opinion in Structural Biology  Journal

abstract

  • There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.

subject areas

  • Animals
  • DNA-Binding Proteins
  • Eukaryotic Cells
  • Humans
  • Protein Binding
  • Protein Folding
  • Signal Transduction
  • Zinc Fingers
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Identity

International Standard Serial Number (ISSN)

  • 0959-440X

Digital Object Identifier (DOI)

  • 10.1016/s0959-440x(02)00289-0

PubMed ID

  • 11839490
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Additional Document Info

start page

  • 54

end page

  • 60

volume

  • 12

issue

  • 1

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