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G-protein-directed ligand discovery with peptide combinatorial libraries

Academic Article
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Overview

authors

  • Ja, William
  • Roberts, R. W.

publication date

  • June 2005

journal

  • Trends in Biochemical Sciences  Journal

abstract

  • Modulators of G-protein signaling have a central role in controlling cell physiology and represent over half of all marketed prescription drugs. G-protein pathways have traditionally been targeted by developing ligands to the extracellular surface of a small subset of the estimated approximately 1000 G-protein-coupled receptors in humans. The intracellular machinery, consisting of the cytosolic receptor surfaces and heterotrimeric G proteins, provides an equivalent diversity of targets that has remained relatively unexplored until now. This review summarizes recent efforts using combinatorial peptide libraries to develop new G-protein signaling modulators targeting intracellular components.

subject areas

  • Combinatorial Chemistry Techniques
  • GTP-Binding Proteins
  • Humans
  • Ligands
  • Peptide Library
  • Peptides
  • RNA, Messenger
  • Receptor Cross-Talk
  • Receptors, G-Protein-Coupled
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2005.04.001

PubMed ID

  • 15950876
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Additional Document Info

start page

  • 318

end page

  • 324

volume

  • 30

issue

  • 6

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