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Different pathways mediate virus inducibility of the human ifn-alpha-1 and ifn-beta genes

Academic Article
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Overview

authors

  • Macdonald, N. J.
  • Kuhl, D.
  • Maguire, D.
  • Naf, D.
  • Gallant, P.
  • Goswamy, A.
  • Hug, H.
  • Bueler, H.
  • Chaturvedi, M.
  • Delafuente, J.
  • Ruffner, H.
  • Meyer, F.
  • Weissmann, Charles

publication date

  • March 1990

journal

  • Cell  Journal

abstract

  • Multimerization of GAAANN generates sequences frequent in virus-inducible promoters. We distinguished different types of (GAAANN)4 sequences mediating virus inducibility. Type I (NN = GT, GC, CT, or CC) responds to IFNs and to IRF-1 and causes silencing. Type II (NN = TG) and type III (NN = CG) neither silence nor respond to IRF-1 or IFN. Type III mediates constitutive transcription and binds the constitutive IEFga factor, whereas type II binds the novel "TG protein". IFN-beta and IFN-alpha 1 promoters contain different response elements: The former has a type I-like sequence (PRDI) and an NF-kappa B-binding sequence (PRDII); the latter has a type II-like "TG sequence" and possibly additional elements but does not bind NF-kappa B. Type I, type II, and NF-kappa B elements represent three distinct terminal pathways mediating virus induction.

subject areas

  • Animals
  • Base Sequence
  • Cell Transformation, Viral
  • Gene Expression Regulation
  • Genes
  • Humans
  • Interferon Type I
  • Interferon-gamma
  • L Cells (Cell Line)
  • Mice
  • Molecular Sequence Data
  • Newcastle disease virus
  • Oligonucleotide Probes
  • Oligonucleotides
  • Plasmids
  • Promoter Regions, Genetic
  • Transcription, Genetic
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(90)90091-r

PubMed ID

  • 2107026
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Additional Document Info

start page

  • 767

end page

  • 779

volume

  • 60

issue

  • 5

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