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Hiv protease inhibitors block human preadipocyte differentiation, but not via the ppar gamma/rxr heterodimer

Academic Article
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Overview

authors

  • Wentworth, J. M.
  • Burris, Thomas
  • Chatterjee, V. K. K.

publication date

  • 2000

journal

  • Journal of Endocrinology  Journal

abstract

  • A recent prospective clinical study has shown that antiviral therapy with HIV protease inhibitors (PIs) is associated with a syndrome of peripheral fat wasting (lipodystrophy) and disordered glucose and lipid metabolism (Carr et al. 1999). We have studied the effects of indinavir and saquinavir, two HIV protease inhibitors, on cultured primary human preadipocytes and report that these compounds inhibit their differentiation. However, we find that these agents do not inhibit either transcriptional activation or adipocyte P2 gene induction by the PPARgamma/RXR nuclear receptor heterodimer. Together, our findings suggest that impaired adipogenesis is the basis of PI-associated lipodystrophy, but that this occurs via a PPARgamma/RXR-independent mechanism.

subject areas

  • Adipocytes
  • Cell Communication
  • Cell Differentiation
  • HIV Protease Inhibitors
  • Humans
  • Indinavir
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Saquinavir
  • Transcription Factors
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Identity

International Standard Serial Number (ISSN)

  • 0022-0795

Digital Object Identifier (DOI)

  • 10.1677/joe.0.164R007

PubMed ID

  • 10657860
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Additional Document Info

start page

  • R7

end page

  • R10

volume

  • 164

issue

  • 2

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