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Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II)

Academic Article
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Overview

authors

  • Sessions, E. H.
  • Chowdhury, S.
  • Yin, Y.
  • Pocas, J. R.
  • Grant, W.
  • Schroter, T.
  • Lin, L.
  • Ruiz, C.
  • Cameron, Michael
  • LoGrasso, Philip
  • Bannister, Thomas
  • Feng, Yangbo

publication date

  • December 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Binding Sites
  • Cytochrome P-450 Enzyme Inhibitors
  • Drug Discovery
  • Enzyme Activation
  • Humans
  • Indoles
  • Inhibitory Concentration 50
  • Models, Molecular
  • Molecular Structure
  • Rats
  • Solubility
  • Water
  • rho-Associated Kinases
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Research

keywords

  • Azaindole
  • Indole
  • Kinase inhibitor
  • Pyrazole
  • ROCK
  • Rho kinase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.09.084

PubMed ID

  • 22018789
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Additional Document Info

start page

  • 7113

end page

  • 7118

volume

  • 21

issue

  • 23

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