Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Randomized, double-blind, placebo-controlled trial of tissue plasminogen-activator in unstable angina

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Nicklas, J. M.
  • Topol, Eric
  • Kander, N.
  • Oneill, W. W.
  • Walton, J. A.
  • Ellis, S. G.
  • Gorman, L.
  • Pitt, B.

publication date

  • February 1989

journal

  • Journal of the American College of Cardiology  Journal

abstract

  • Angiographic, angioscopic and pathologic reports have recently demonstrated a high incidence of intracoronary thrombus in patients with unstable angina. To determine if thrombolysis could be beneficial when combined with maximal medical therapy, 40 patients with rest angina, angiographically documented coronary artery disease and pacing-induced ischemia were randomly assigned to intravenous recombinant tissue-type plasminogen activator (rt-PA, 150 mg/8 h) or placebo in a prospective double-blind trial. All patients received nitrates, a beta-adrenergic blocking agent, a calcium channel blocker, aspirin and heparin. Pacing thresholds for ischemia and quantitative coronary stenosis were measured before and after infusion of the study medication. Intracoronary thrombus was identified angiographically before infusion of the study medication in 16 patients; 7 received rt-PA and 9 received placebo. The ischemic pacing threshold in patients treated with rt-PA increased from 112 +/- 4 beats/min at baseline to 127 +/- 5 beats/min (p = 0.007) by the end of the infusion versus an insignificant change in patients who received placebo (from 116 +/- 4 to 119 +/- 4 beats/min, p = NS). In patients with intracoronary thrombus, the ischemic pacing threshold increased 26 +/- 7 beats/min with rt-PA treatment versus 0 +/- 3 beats/min with placebo (p = 0.004). In contrast, in patients without thrombus, there was no difference in ischemic pacing threshold increments between treatment groups (7 +/- 11 beats/min for rt-PA versus 6 +/- 5 beats/min for placebo, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)

subject areas

  • Adolescent
  • Adult
  • Aged
  • Angina Pectoris
  • Angina, Unstable
  • Cardiac Pacing, Artificial
  • Clinical Trials as Topic
  • Coronary Angiography
  • Coronary Disease
  • Double-Blind Method
  • Electrocardiography
  • Female
  • Fibrinolysis
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Random Allocation
  • Tissue Plasminogen Activator
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0735-1097

PubMed ID

  • 2492325
scroll to property group menus

Additional Document Info

start page

  • 434

end page

  • 441

volume

  • 13

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support