Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Burudi, E. M. E.
  • Marcondes, Maria Cecilia
  • Watry, D. D.
  • Zandonatti, M.
  • Taffe, Michael
  • Fox, H. S.

publication date

  • December 2002

journal

  • Journal of Virology  Journal

abstract

  • The human immunodeficiency virus type 1-associated cognitive-motor disorder, including the AIDS dementia complex, is characterized by brain functional abnormalities that are associated with injury initiated by viral infection of the brain. Indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme in tryptophan catabolism in extrahepatic tissues, can lead to neurotoxicity through the generation of quinolinic acid and immunosuppression and can alter brain chemistry via depletion of tryptophan. Using the simian immunodeficiency virus (SIV)-infected rhesus macaque model of AIDS, we demonstrate that cells of the macrophage lineage are the main source for expression of IDO in the SIV-infected monkey brain. Animals with SIV encephalitis have the highest levels of IDO mRNA, and the level of IDO correlates with gamma interferon (IFN-gamma) and viral load levels. In vitro studies on mouse microglia reveal that IFN-gamma is the primary inducer of IDO expression. These findings demonstrate the link between IDO expression, IFN-gamma levels, and brain pathology signs observed in neuro-AIDS.

subject areas

  • AIDS Dementia Complex
  • Animals
  • Base Sequence
  • Brain
  • Disease Models, Animal
  • Gene Expression Regulation, Enzymologic
  • Humans
  • In Vitro Techniques
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Interferon-gamma
  • Macaca mulatta
  • Mice
  • Microglia
  • Molecular Sequence Data
  • RNA, Messenger
  • Recombinant Proteins
  • Simian Acquired Immunodeficiency Syndrome
  • Tryptophan Oxygenase
  • Tumor Necrosis Factor-alpha
scroll to property group menus

Identity

PubMed Central ID

  • PMC136861

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.76.23.12233-12241.2002

PubMed ID

  • 12414962
scroll to property group menus

Additional Document Info

start page

  • 12233

end page

  • 12241

volume

  • 76

issue

  • 23

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support