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The nuclear membrane proteome: extending the envelope

Academic Article
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Overview

authors

  • Schirmer, E. C.
  • Gerace, Larry

publication date

  • October 2005

journal

  • Trends in Biochemical Sciences  Journal

abstract

  • The marriage of proteomics with cell biology has produced extensive inventories of the proteins that inhabit several subcellular organelles. Recent proteomic analysis has identified many new putative transmembrane proteins in the nuclear envelope, and transcriptome profiling suggests that the nuclear-membrane proteome exhibits some significant variations among different tissues. Cell-type-specific differences in the composition of protein sub-complexes of the nuclear envelope, particularly those containing the disease-associated protein lamin A, could yield distinctive functions and, thus, explain the tissue specificity of a diverse group of nuclear-envelope-linked disorders in humans. Considered together, these recent results suggest an unexpected functional complexity at the nuclear envelope.

subject areas

  • Animals
  • Humans
  • Membrane Proteins
  • Nuclear Envelope
  • Proteomics
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Identity

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2005.08.003

PubMed ID

  • 16125387
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Additional Document Info

start page

  • 551

end page

  • 558

volume

  • 30

issue

  • 10

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