Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Dauwalder, B.
  • Davis, Ronald

publication date

  • 1995

journal

  • Journal of Neuroscience  Journal

abstract

  • Mutations in the Drosophila dunce gene, the structural gene for a cAMP-specific phosphodiesterase (PDE), disrupt normal learning and memory and lead to female sterility. Our experiments address a long-standing question in the genetic dissection of learning and memory of whether dnc is involved in physiological processes underlying learning. Conditional expression of dunce transgenes in dnc adults shortly before training significantly improves learning over nontransgenic controls. Remarkably, behavioral rescue was also observed after induction of a transgene carrying a rat counterpart of dunce. Induction of the transgenes in adult dnc females confers partial rescue of the female sterility phenotype. These data are consistent with a major physiological requirement for the gene's activity in the learning process and show that a rat counterpart can substitute functionally for the Drosophila gene.

subject areas

  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Animals
  • Animals, Genetically Modified
  • Base Sequence
  • Cell Line, Transformed
  • Crosses, Genetic
  • DNA Transposable Elements
  • Drosophila
  • Female
  • Fertility
  • Gene Expression
  • Genes
  • Genotype
  • Heat-Shock Proteins
  • Hot Temperature
  • Infertility, Female
  • Kinetics
  • Learning
  • Male
  • Memory
  • Molecular Sequence Data
  • Mutagenesis
  • Rats
  • Restriction Mapping
scroll to property group menus

Research

keywords

  • CAMP PHOSPHODIESTERASE
  • CLASSICAL CONDITIONING
  • DROSOPHILA
  • DUNCE GENE
  • RESCUE OF DUNCE PHENOTYPES
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0270-6474

PubMed ID

  • 7751924
scroll to property group menus

Additional Document Info

start page

  • 3490

end page

  • 3499

volume

  • 15

issue

  • 5

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support