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Strategies to achieve coronary arterial plaque stabilization

Academic Article
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Overview

authors

  • Rabbani, R.
  • Topol, Eric

publication date

  • 1999

journal

  • Cardiovascular Research  Journal

abstract

  • Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool, an abundance of inflammatory cells and mediators, a reduced smooth muscle cell and collagen content and a thin overlying fibrous cap. Potential therapeutic strategies at achieving plaque stabilization have targeted these features. Lipid lowering agents, beta-adrenergic blockers, angiotensin converting enzyme inhibitors and antioxidants have been shown to reduce the incidence of acute coronary syndromes, presumably through plaque stabilization. Matrix metalloproteinase inhibitors as well as macrolide antibiotics and gene therapy approaches show promise in achieving plaque stabilization. The evidence supporting plaque stabilization by these agents and the mechanisms by which these agents stabilize plaques are discussed in detail in this review.

subject areas

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Animals
  • Anti-Bacterial Agents
  • Antioxidants
  • Coronary Artery Disease
  • Female
  • Genetic Therapy
  • Humans
  • Hypolipidemic Agents
  • Macrolides
  • Male
  • Metalloendopeptidases
  • Myocardial Infarction
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Research

keywords

  • acute coronary syndromes
  • atherosclerosis
  • hydroxymethylglutaryl-CoA reductase
  • lipid lowering
  • matrix metalloprotcinase
  • plaque rupture
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Identity

International Standard Serial Number (ISSN)

  • 0008-6363

Digital Object Identifier (DOI)

  • 10.1016/s0008-6363(98)00279-x

PubMed ID

  • 10341840
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Additional Document Info

start page

  • 402

end page

  • 417

volume

  • 41

issue

  • 2

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