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Inhibition by mk-801 of morphine-induced conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

Academic Article
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Overview

authors

  • Kim, H. S.
  • Jang, Choon-Gon
  • Park, W. K.

publication date

  • September 1996

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • Intraperitoncel injection of morphine (5 mg/kg) in mice every other day for 8 days produced conditioned place preference (CPP). CPP effects were evaluated by assessing the difference in time spent in the drug-paired compartment and the saline-paired compartment of the place conditioning apparatus. The injection of a noncompetitive NMDA antagonist, MK-801 (0.05 and 0.1 mg/kg. IP), prior to and during morphine treatment in mice inhibited morphine-induced CPP. The development of postsynaptic dopamine (DA) receptor supersensitivity in mice displaying a morphine-induced CPP was evidenced by the enhanced response in ambulatory activity to the DA agonist, apomorphine (2 mg/kg). MK-801 inhibited that development of postsynaptic DA receptor supersensitivity. MK-801 also inhibited apomorphine-induced climbing behavior, suggesting that MK-801 inhibits dopaminergic activation mediated via the NMDA receptor. These results suggest that the development of morphine-induced CPP may be associated with the development of postsynaptic DA receptor supersensitivity. The development of morphine-induced CPP and DA receptor supersensitivity may be closely related to NMDA receptor-mediated dopaminergic activity, because morphine-induced changes in sensitivity to apomorphine, as well as apomorphine-induced climbing behavior in morphine treated mice, were both blocked by MK-801.

subject areas

  • Animals
  • Apomorphine
  • Conditioning, Operant
  • Dizocilpine Maleate
  • Dopamine Agonists
  • Excitatory Amino Acid Antagonists
  • Male
  • Mice
  • Mice, Inbred ICR
  • Morphine
  • Narcotic Antagonists
  • Narcotics
  • Receptors, Dopamine
  • Receptors, Neurotransmitter
  • Stereotyped Behavior
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Research

keywords

  • CPP
  • DA receptor supersensitivity
  • MK-801
  • morphine
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(96)00078-0

PubMed ID

  • 8870032
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Additional Document Info

start page

  • 11

end page

  • 17

volume

  • 55

issue

  • 1

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