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Regulation of thymus size by competition for stromal niches among early T cell progenitors

Academic Article
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Overview

authors

  • Prockop, S. E.
  • Petrie, Howard

publication date

  • August 2004

journal

  • Journal of Immunology  Journal

abstract

  • Thymic T cell production is characterized by differentiating waves of non-self-renewing, bone marrow-derived progenitors. The factors constraining new progenitor recruitment, intrathymic precursor expansion, and thymus size remain enigmatic, but are believed to be controlled by a feedback loop responding to lymphoid cellularity and competition for stromal niches. In this study, we show that competition for stromal niches does occur, but is solely limited to cells at the early CD4(-)8(-) precursor stages of differentiation. The overall size of the organ is determined both by this limitation on early precursor expansion, and by a second, cell-intrinsic limit on expansion of progenitor cells transiting to the CD4(+)8(+) stage. Together with asymmetric use of marrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous generation of new T cells while maintaining a relatively stable organ size.

subject areas

  • Animals
  • Animals, Congenic
  • Antigens, CD4
  • Antigens, CD45
  • Antigens, CD8
  • Bone Marrow Transplantation
  • Cell Differentiation
  • DNA-Binding Proteins
  • Genes, Reporter
  • Green Fluorescent Proteins
  • Interleukin Receptor Common gamma Subunit
  • Janus Kinase 3
  • Luminescent Proteins
  • Lymphocytes, Null
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, SCID
  • Mice, Transgenic
  • Organ Size
  • Protein-Tyrosine Kinases
  • Radiation Chimera
  • Receptors, Interleukin-7
  • Specific Pathogen-Free Organisms
  • T-Lymphocyte Subsets
  • Thymus Gland
  • Transplantation Chimera
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 15265888
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Additional Document Info

start page

  • 1604

end page

  • 1611

volume

  • 173

issue

  • 3

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