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The art of total synthesis through cascade reactions

Academic Article
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Overview

authors

  • Nicolaou, K.C.
  • Chen, Jason Shih-Hao

publication date

  • 2009

journal

  • Chemical Society Reviews  Journal

abstract

  • The growing importance of cascade reactions reflects and imparts advances in the state of the art of organic synthesis and underscores the desire of synthetic chemists to achieve higher levels of elegance and efficiency. Besides their esthetic appeal, cascade processes offer economical and environmentally friendly means for generating molecular complexity. Because of their many advantages, these reactions have found numerous applications in the synthesis of complex molecules, both natural and designed. In this tutorial review, we highlight the design and execution of cascade reactions within the context of total synthesis as demonstrated with selected examples from these laboratories.

subject areas

  • Biological Products
  • Organic Chemicals
  • Organic Chemistry Processes
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Identity

PubMed Central ID

  • PMC2766600

International Standard Serial Number (ISSN)

  • 0306-0012

Digital Object Identifier (DOI)

  • 10.1039/b903290h

PubMed ID

  • 19847336
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Additional Document Info

start page

  • 2993

end page

  • 3009

volume

  • 38

issue

  • 11

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