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Commitment and developmental potential of extrathymic and intrathymic T cell precursors: Plenty to choose from

Academic Article
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Overview

authors

  • Bhandoola, A.
  • von Boehmer, H.
  • Petrie, Howard
  • Zuniga-Pflucker, J. C.

publication date

  • June 2007

journal

  • Immunity  Journal

abstract

  • T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.

subject areas

  • Animals
  • B-Lymphocytes
  • Bone Marrow
  • Bone Marrow Transplantation
  • Cell Lineage
  • Hematopoietic Stem Cells
  • Humans
  • T-Lymphocytes
  • Thymus Gland
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Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2007.05.009

PubMed ID

  • 17582341
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Additional Document Info

start page

  • 678

end page

  • 689

volume

  • 26

issue

  • 6

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