recent publications
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academic article
- Zhang, K., Huentelman, M. J., Rao, F., Sun, E. I., Corneveaux, J. J., Schork, A. J., Wei, Z., Waalen, J., Miramontes-Gonzalez, J. P., Hightower, C. M., Maihofer, A. X., Mahata, M., et al. Genetic implication of a novel thiamine transporter in human hypertension Journal of the American College of Cardiology 2014 63:1542-1555 DOI:10.1016/j.jacc.2014.01.007 PMID:24509276 PMCID:PMC3992204
- Zhang, K. X., Rao, F. W., Miramontes-Gonzalez, J. P., Hightower, C. M., Vaught, B., Chen, Y. H., Greenwood, T. A., Schork, A. J., Wang, L., Mahata, M., Stridsberg, M., Khandrika, S., et al. Neuropeptide y (npy) genetic variation in the human promoter alters glucocorticoid signaling, yielding increased npy secretion and stress responses Journal of the American College of Cardiology 2012 60:1678-1689 DOI:10.1016/j.jacc.2012.06.042 PMID:23021333 PMCID:PMC3687554
- Mbewe-Campbell, N., Wei, Z. Y., Zhang, K. X., Friese, R. S., Mahata, M., Schork, A. J., Rao, F. W., Chiron, S., Biswas, N., Kim, H. S., Mahata, S. K., Waalen, J., et al. Genes and environment: Novel, functional polymorphism in the human cathepsin l (ctsl1) promoter disrupts a xenobiotic response element (xre) to alter transcription and blood pressure Journal of Hypertension 2012 30:1961-1969 DOI:10.1097/HJH.0b013e328356b86a PMID:22871890 PMCID:PMC3478326
- Chen, Y. Q., Zhang, K. X., Wen, G., Rao, F. W., Sanchez, A. P., Wang, L., Rodriguez-Flores, J. L., Mahata, M., Mahata, S. K., Waalen, J., Ziegler, M. G., Hamilton, B. A., et al. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure American Journal of Hypertension 2011 24:24-32 DOI:10.1038/ajh.2010.186 PMID:20814407 PMCID:PMC4906639
- Jirout, M. L., Friese, R. S., Mahapatra, N. R., Mahata, M., Taupenot, L., Mahata, S. K., Kren, V., Zidek, V., Fischer, J., Maatz, H., Ziegler, M. G., Pravenec, M., et al. Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat Human Molecular Genetics 2010 19:2567-2580 DOI:10.1093/hmg/ddq135 PMID:20378607 PMCID:PMC2883337
- Zhang, K. X., Rao, F. W., Wang, L., Rana, B. K., Ghosh, S., Mahata, M., Salem, R. M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Tayo, B., Taupenot, L., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension Journal of the American College of Cardiology 2010 55:1463-1475 DOI:10.1016/j.jacc.2009.11.064 PMID:20359597 PMCID:PMC2889490
- Chen, Y. Q., Salem, R. M., Rao, F. W., Fung, M. M., Bhatnagar, V., Pandey, B., Mahata, M., Waalen, J., Nievergelt, C. M., Lipkowitz, M. S., Hamilton, B. A., Mahata, S. K., et al. Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease American Journal of Nephrology 2010 32:414-424 DOI:10.1159/000320131 PMID:20861615 PMCID:PMC2975731
- Chen, Y. Q., Wen, G., Rao, F. W., Zhang, K. X., Wang, L., Rodriguez-Flores, J. L., Sanchez, A. P., Mahata, M., Taupenot, L., Sun, P., Mahata, S. K., Tayo, B., et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Journal of Hypertension 2010 28:76-86 DOI:10.1097/HJH.0b013e328332bc87 PMID:20009769 PMCID:PMC2860271
- Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Fung, M. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Hicks, P. J., Bowden, D. W., et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis American Journal of Nephrology 2010 32:23-30 DOI:10.1159/000313927 PMID:20484896 PMCID:PMC2914391
- Fung, M. M., Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Brophy, V. H., O'Connor, D. T., et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis Nephrology Dialysis Transplantation 2009 24:3677-3686 DOI:10.1093/ndt/gfp471 PMID:19745105 PMCID:PMC2790952
- Wang, L., Rao, F. W., Zhang, K. X., Mahata, M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Cockburn, M. G., Hamilton, B. A., Mahata, S. K., O'Connor, D. T. Neuropeptide y(1) receptor npy1r discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo Journal of the American College of Cardiology 2009 54:944-954 DOI:10.1016/j.jacc.2009.05.035 PMID:19712806 PMCID:PMC2792636
- Zhang, K. X., Rao, F. W., Rana, B. K., Gayen, J. R., Calegari, F., King, A., Rosa, P., Huttner, W. B., Stridsberg, M., Mahata, M., Vaingankar, S., Mahboubi, V., et al. Autonomic function in hypertension role of genetic variation at the catecholamine storage vesicle protein chromogranin b Circulation-Cardiovascular Genetics 2009 2:46-56 DOI:10.1161/circgenetics.108.785659 PMID:20011129 PMCID:PMC2792940
- Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology 2008 52:1468-1481 DOI:10.1016/j.jacc.2008.07.047 PMID:19017515 PMCID:PMC2659417
- Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International 2008 74:115-125 DOI:10.1038/ki.2008.113 PMID:18432188 PMCID:PMC2576285
- Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology 2008 19:600-614 DOI:10.1681/asn.2007070754 PMID:18235090 PMCID:PMC2391050
- Rao, F., Wen, G., Gayen, J. R., Das, M., Vaingankar, S. M., Rana, B. K., Mahata, M., Kennedy, B. P., Salem, R. M., Stridsberg, M., Abel, K., Smith, D. W., et al. Catecholamine release-inhibitory peptide catestatin (chromogranin a(352-372)) - naturally occurring amino acid variant gly364ser causes profound changes in human autonomic activity and alters risk for hypertension Circulation 2007 115:2271-2281 DOI:10.1161/circulationaha.106.628859 PMID:17438154
- Lillie, E. O., Mahata, M., Khandrika, S., Rao, F., Bundey, R. A., Wen, G., Chen, Y. Q., Taupenot, L., Smith, D. W., Mahata, S. K., Ziegler, M. G., Cockburn, M., et al. Heredity of endothelin secretion - human twin studies reveal the influence of polymorphism at the chromogranin a locus, a novel determinant of endothelial function Circulation 2007 115:2282-2291 DOI:10.1161/circulationaha.106.648345 PMID:17438153
- Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B. K., Kennedy, B. P., Khandrika, S., Huang, P., Lillie, E. O., Shih, P. A. B., et al. C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci Journal of Hypertension 2007 25:329-343 DOI:10.1097/HJH.0b013e328011753e PMID:17211240
- Greenwood, T. A., Rao, F. W., Stridsberg, M., Mahapatra, N. R., Mahata, M., Lillie, E. O., Mahata, S. K., Taupenot, L., Schork, N. J., O'Connor, D. T. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion Physiological Genomics 2006 25:470-479 DOI:10.1152/physiolgenomics.00295.2005 PMID:16554546
- Wen, G., Mahata, S. K., Cadman, P., Mahata, M., Ghosh, S., Mahapatra, N. R., Rao, F. W., Stridsberg, M., Smith, D. W., Mahboubi, P., Schork, N. J., O'Connor, D. T., et al. Both rare and common polymorphisms contribute functional variation at chga, a regulator of catecholamine physiology American Journal of Human Genetics 2004 74:197-207 DOI:10.1086/381399 PMID:14740315 PMCID:PMC1181918
- Jiang, Q. J., Taupenot, L., Mahata, S. K., Mahata, M., O'Connor, D. T., Miles, L. A., Parmer, R. J. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release Journal of Biological Chemistry 2001 276:25022-25029 DOI:10.1074/jbc.M101545200 PMID:11342539
- Parmer, R. J., Mahata, M., Gong, Y., Mahata, S. K., Jiang, Q. J., O'Connor, D. T., Xi, X. P., Miles, L. A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion Journal of Clinical Investigation 2000 106:907-915 DOI:10.1172/jci7394 PMID:11018079 PMCID:PMC381423
- Parmer, R. J., Mahata, S. K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O'Connor, D. T., Miles, L. A. Tissue plasminogen activator and chromaffin cell function Advances in Experimental Medicine and Biology 2000 482:179-192 DOI:10.1007/0-306-46837-9_14 PMID:11192579
- Parmer, R. J., Mahata, M., Mahata, S., Sebald, M. T., O'Connor, D. T., Miles, L. A. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA Journal of Biological Chemistry 1997 272:1976-1982 PMID:8999889