recent publications

• academic article

  • Zhang, K., Huentelman, M. J., Rao, F., Sun, E. I., Corneveaux, J. J., Schork, A. J., Wei, Z., Waalen, J., Miramontes-Gonzalez, J. P., Hightower, C. M., Maihofer, A. X., Mahata, M., et al. Genetic implication of a novel thiamine transporter in human hypertension Journal of the American College of Cardiology  2014 63:1542-1555  DOI:10.1016/j.jacc.2014.01.007  PMID:24509276  PMCID:PMC3992204
  • Mbewe-Campbell, N., Wei, Z. Y., Zhang, K. X., Friese, R. S., Mahata, M., Schork, A. J., Rao, F. W., Chiron, S., Biswas, N., Kim, H. S., Mahata, S. K., Waalen, J., et al. Genes and environment: Novel, functional polymorphism in the human cathepsin l (ctsl1) promoter disrupts a xenobiotic response element (xre) to alter transcription and blood pressure Journal of Hypertension  2012 30:1961-1969  DOI:10.1097/HJH.0b013e328356b86a  PMID:22871890  PMCID:PMC3478326
  • Zhang, K. X., Rao, F. W., Miramontes-Gonzalez, J. P., Hightower, C. M., Vaught, B., Chen, Y. H., Greenwood, T. A., Schork, A. J., Wang, L., Mahata, M., Stridsberg, M., Khandrika, S., et al. Neuropeptide y (npy) genetic variation in the human promoter alters glucocorticoid signaling, yielding increased npy secretion and stress responses Journal of the American College of Cardiology  2012 60:1678-1689  DOI:10.1016/j.jacc.2012.06.042  PMID:23021333  PMCID:PMC3687554
  • Chen, Y. Q., Zhang, K. X., Wen, G., Rao, F. W., Sanchez, A. P., Wang, L., Rodriguez-Flores, J. L., Mahata, M., Mahata, S. K., Waalen, J., Ziegler, M. G., Hamilton, B. A., et al. Human dopamine beta-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure American Journal of Hypertension  2011 24:24-32  DOI:10.1038/ajh.2010.186  PMID:20814407  PMCID:PMC4906639
  • Chen, Y. Q., Salem, R. M., Rao, F. W., Fung, M. M., Bhatnagar, V., Pandey, B., Mahata, M., Waalen, J., Nievergelt, C. M., Lipkowitz, M. S., Hamilton, B. A., Mahata, S. K., et al. Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease American Journal of Nephrology  2010 32:414-424  DOI:10.1159/000320131  PMID:20861615  PMCID:PMC2975731
  • Zhang, K. X., Rao, F. W., Wang, L., Rana, B. K., Ghosh, S., Mahata, M., Salem, R. M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Tayo, B., Taupenot, L., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension Journal of the American College of Cardiology  2010 55:1463-1475  DOI:10.1016/j.jacc.2009.11.064  PMID:20359597  PMCID:PMC2889490
  • Jirout, M. L., Friese, R. S., Mahapatra, N. R., Mahata, M., Taupenot, L., Mahata, S. K., Kren, V., Zidek, V., Fischer, J., Maatz, H., Ziegler, M. G., Pravenec, M., et al. Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat Human Molecular Genetics  2010 19:2567-2580  DOI:10.1093/hmg/ddq135  PMID:20378607  PMCID:PMC2883337
  • Chen, Y. Q., Wen, G., Rao, F. W., Zhang, K. X., Wang, L., Rodriguez-Flores, J. L., Sanchez, A. P., Mahata, M., Taupenot, L., Sun, P., Mahata, S. K., Tayo, B., et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure Journal of Hypertension  2010 28:76-86  DOI:10.1097/HJH.0b013e328332bc87  PMID:20009769  PMCID:PMC2860271
  • Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Fung, M. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Hicks, P. J., Bowden, D. W., et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis American Journal of Nephrology  2010 32:23-30  DOI:10.1159/000313927  PMID:20484896  PMCID:PMC2914391
  • Fung, M. M., Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Brophy, V. H., O'Connor, D. T., et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis Nephrology Dialysis Transplantation  2009 24:3677-3686  DOI:10.1093/ndt/gfp471  PMID:19745105  PMCID:PMC2790952
  • Zhang, K. X., Rao, F. W., Rana, B. K., Gayen, J. R., Calegari, F., King, A., Rosa, P., Huttner, W. B., Stridsberg, M., Mahata, M., Vaingankar, S., Mahboubi, V., et al. Autonomic function in hypertension role of genetic variation at the catecholamine storage vesicle protein chromogranin b Circulation-Cardiovascular Genetics  2009 2:46-56  DOI:10.1161/circgenetics.108.785659  PMID:20011129  PMCID:PMC2792940
  • Wang, L., Rao, F. W., Zhang, K. X., Mahata, M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Cockburn, M. G., Hamilton, B. A., Mahata, S. K., O'Connor, D. T. Neuropeptide y(1) receptor npy1r discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo Journal of the American College of Cardiology  2009 54:944-954  DOI:10.1016/j.jacc.2009.05.035  PMID:19712806  PMCID:PMC2792636
  • Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology  2008 19:600-614  DOI:10.1681/asn.2007070754  PMID:18235090  PMCID:PMC2391050
  • Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International  2008 74:115-125  DOI:10.1038/ki.2008.113  PMID:18432188  PMCID:PMC2576285
  • Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology  2008 52:1468-1481  DOI:10.1016/j.jacc.2008.07.047  PMID:19017515  PMCID:PMC2659417
  • Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B. K., Kennedy, B. P., Khandrika, S., Huang, P., Lillie, E. O., Shih, P. A. B., et al. C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci Journal of Hypertension  2007 25:329-343  DOI:10.1097/HJH.0b013e328011753e  PMID:17211240
  • Rao, F., Wen, G., Gayen, J. R., Das, M., Vaingankar, S. M., Rana, B. K., Mahata, M., Kennedy, B. P., Salem, R. M., Stridsberg, M., Abel, K., Smith, D. W., et al. Catecholamine release-inhibitory peptide catestatin (chromogranin a(352-372)) - naturally occurring amino acid variant gly364ser causes profound changes in human autonomic activity and alters risk for hypertension Circulation  2007 115:2271-2281  DOI:10.1161/circulationaha.106.628859  PMID:17438154
  • Lillie, E. O., Mahata, M., Khandrika, S., Rao, F., Bundey, R. A., Wen, G., Chen, Y. Q., Taupenot, L., Smith, D. W., Mahata, S. K., Ziegler, M. G., Cockburn, M., et al. Heredity of endothelin secretion - human twin studies reveal the influence of polymorphism at the chromogranin a locus, a novel determinant of endothelial function Circulation  2007 115:2282-2291  DOI:10.1161/circulationaha.106.648345  PMID:17438153
  • Greenwood, T. A., Rao, F. W., Stridsberg, M., Mahapatra, N. R., Mahata, M., Lillie, E. O., Mahata, S. K., Taupenot, L., Schork, N. J., O'Connor, D. T. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion Physiological Genomics  2006 25:470-479  DOI:10.1152/physiolgenomics.00295.2005  PMID:16554546
  • Wen, G., Mahata, S. K., Cadman, P., Mahata, M., Ghosh, S., Mahapatra, N. R., Rao, F. W., Stridsberg, M., Smith, D. W., Mahboubi, P., Schork, N. J., O'Connor, D. T., et al. Both rare and common polymorphisms contribute functional variation at chga, a regulator of catecholamine physiology American Journal of Human Genetics  2004 74:197-207  DOI:10.1086/381399  PMID:14740315  PMCID:PMC1181918
  • Jiang, Q. J., Taupenot, L., Mahata, S. K., Mahata, M., O'Connor, D. T., Miles, L. A., Parmer, R. J. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release Journal of Biological Chemistry  2001 276:25022-25029  DOI:10.1074/jbc.M101545200  PMID:11342539
  • Parmer, R. J., Mahata, M., Gong, Y., Mahata, S. K., Jiang, Q. J., O'Connor, D. T., Xi, X. P., Miles, L. A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion Journal of Clinical Investigation  2000 106:907-915  DOI:10.1172/jci7394  PMID:11018079  PMCID:PMC381423
  • Parmer, R. J., Mahata, S. K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O'Connor, D. T., Miles, L. A. Tissue plasminogen activator and chromaffin cell function Advances in Experimental Medicine and Biology  2000 482:179-192  DOI:10.1007/0-306-46837-9_14  PMID:11192579
  • Parmer, R. J., Mahata, M., Mahata, S., Sebald, M. T., O'Connor, D. T., Miles, L. A. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA Journal of Biological Chemistry  1997 272:1976-1982  PMID:8999889