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Cell cooperation during in vivo anti-hapten antibody responses. VI. Evidence for an allogeneic effect replacing one of two helper T cells

Academic Article
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Overview

authors

  • Janeway, C. A.
  • Bert, D. L.
  • Mosier, Donald

publication date

  • 1980

journal

  • European Journal of Immunology  Journal

abstract

  • T and B lymphocyte activity in adoptive secondary antibody responses was assessed by cell titration in mice of the X-linked immune defective CBA/N strain and mice of their normal partner strain CBA/CaJ. No quantitative differences could be detected in either T or B cell activity in these experiments, in which 2,4-dinitrophenyl was used as the hapten. Both of the helper T cells detected in such assays were present in both strains. During these experiments, it was found that a subline of CBA/N maintained at Yale may have diverged from the CBA/N NIH stock. This was detected by an ability of irradiated mice of the Yale subline to increase the antibody response of B cells from the NIH subline, provided specific helper T cells were also present. This allogeneic effect apparently replaced the activity of one helper T cell, but did not replace the requirement for a carrier-specific helper T cell.

subject areas

  • Animals
  • Antibody Formation
  • B-Lymphocytes
  • Dinitrobenzenes
  • Haptens
  • Immunologic Memory
  • Isoantigens
  • Lymphocyte Cooperation
  • Lymphocyte Culture Test, Mixed
  • Male
  • Mice
  • Mice, Inbred CBA
  • Ovalbumin
  • Radiation Chimera
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830100403

PubMed ID

  • 6447074
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Additional Document Info

start page

  • 236

end page

  • 241

volume

  • 10

issue

  • 4

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