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Role of CCL2/MCP-1 in islet transplantation

Academic Article
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Overview

authors

  • Melzi, R.
  • Mercalli, A.
  • Sordi, V.
  • Cantarelli, E.
  • Nano, R.
  • Maffi, P.
  • Sitia, G.
  • Guidotti, Luca
  • Secchi, A.
  • Bonifacio, E.
  • Piemonti, L.

publication date

  • 2010

journal

  • Cell Transplantation  Journal

abstract

  • High levels of donor-derived CCL2 have been associated with poor islet allograft outcome in patients with type 1 diabetes. The aim of our work was to determine whether CCL2 secreted by the islet has independent proinflammatory effects that influence engraftment and graft acceptance. Both in mice and humans CCL2 is significantly positively associated with other cytokines/chemokines, in particular with the highly released "proinflammatory" IL-6 and CXCL8 or CXCL1. Transplantation of CCL2-/- islets into syngenic recipients did not improve the transplant function. Transplantation of islets into CCL2-/- syngenic recipients led to a significant improvement of transplant function and partial abrogation of local hepatic inflammation. When evaluated in human islets CCL2 release was strongly related to the immediate local inflammatory response in the liver and impacted short-term human islet function dependently by the induced inflammatory response and independently by the immunosuppressive therapy. The data showed that islet CCL2 release is a sign of "inflamed" islets without having a direct role in graft failure. On the other hand, a causal effect for developing detrimental proinflammatory conditions after transplant was proved for recipient CCL2. Strategies to selectively decrease recipient, but not donor, CCL2 release may increase the success of islet transplantation.

subject areas

  • Adult
  • Animals
  • Chemokine CCL2
  • Chemokine CXCL1
  • Diabetes Mellitus, Type 1
  • Disease Models, Animal
  • Female
  • Humans
  • Inflammation
  • Interleukin-6
  • Interleukin-8
  • Islets of Langerhans Transplantation
  • Male
  • Mice
  • Mice, Knockout
  • Middle Aged
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Research

keywords

  • Engraftment
  • Human model
  • Islet transplantation
  • Mouse model
  • Portal vein
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Identity

International Standard Serial Number (ISSN)

  • 0963-6897

Digital Object Identifier (DOI)

  • 10.3727/096368910x514639

PubMed ID

  • 20546673
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Additional Document Info

start page

  • 1031

end page

  • 1046

volume

  • 19

issue

  • 8

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