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Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis

Academic Article
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Overview

authors

  • Lotz, Martin
  • Carson, D. A.
  • Vaughan, J. H.

publication date

  • 1987

journal

  • Science  Journal

abstract

  • Several clinical features are consistent with nervous system involvement in the pathogenesis of rheumatoid arthritis. The neuropeptide substance P is one possible mediator of this interaction, since it can be released into joint tissues from primary sensory nerve fibers. The potential effects of the peptide on rheumatoid synoviocytes were examined. The results show that substance P stimulates prostaglandin E2 and collagenase release from synoviocytes. Furthermore, synoviocyte proliferation was increased in the presence of the neuropeptide. Similar effects were observed with a truncated form of substance P. Synoviocytes were sensitive to very small doses of the neuropeptide (10(-9) M), and its effects were inhibited by a specific antagonist. Thus, the specific stimulation of synoviocytes by the neuropeptide substance P represents a pathway by which the nervous system might be directly involved in the pathogenesis of rheumatoid arthritis.

subject areas

  • Arthritis, Rheumatoid
  • Dinoprostone
  • Humans
  • In Vitro Techniques
  • Microbial Collagenase
  • Prostaglandins E
  • Substance P
  • Synovial Membrane
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2433770

PubMed ID

  • 2433770
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Additional Document Info

start page

  • 893

end page

  • 895

volume

  • 235

issue

  • 4791

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