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Clonal deletion of autospecific lymphocytes-b

Academic Article
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Overview

authors

  • Nemazee, David
  • Russell, D.
  • Arnold, B.
  • Haemmerling, G.
  • Allison, J.
  • Miller, Jfap
  • Morahan, G.
  • Buerki, K.

publication date

  • August 1991

journal

  • Immunological Reviews  Journal

abstract

  • Using mice transgenic for functional, rearranged immunoglobulin heavy and light chain genes, it can be demonstrated that B lymphocytes reactive with cell surface-bound class I MHC antigen can be controlled by clonal elimination. Even low-affinity cell-bound ligands can induce deletion. Deletion can occur in the pre-B to B cell transitional stage or after the B cells exist the bone marrow, depending on where the cells first encounter autoantigen. IgD appears to play no role in protecting cells from deletion. It is argued that defects in B-cell tolerance alone may be sufficient to lead to systemic autoimmunity.

subject areas

  • Animals
  • Autoantigens
  • B-Lymphocytes
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain
  • Gene Rearrangement, B-Lymphocyte, Light Chain
  • Histocompatibility Antigens Class I
  • Immune Tolerance
  • Mice
  • Mice, Transgenic
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Identity

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065X.1991.tb00600.x

PubMed ID

  • 1937539
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Additional Document Info

start page

  • 117

end page

  • 132

volume

  • 122

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