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Area specificity and topography of thalamocortical projections are controlled by ephrin/eph genes

Academic Article
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Overview

authors

  • Dufour, A.
  • Seibt, J.
  • Passante, L.
  • Depaepe, V.
  • Ciossek, T.
  • Frisen, J.
  • Kullander, K.
  • Flanagan, J. G.
  • Polleux, Franck
  • Vanderhaeghen, P.

publication date

  • 2003

journal

  • Neuron  Journal

abstract

  • The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamocortical (TC) axons. In addition, we show that the same ephrin/Eph genes unexpectedly control the inter-areal specificity of TC projections through the early topographic sorting of TC axons in an intermediate target, the ventral telencephalon. Our results constitute the first identification of guidance cues involved in inter-areal specificity of TC projections and demonstrate that the same set of mapping labels is used differentially for the generation of topographic specificity of TC projections between and within individual cortical areas.

subject areas

  • Animals
  • Brain Mapping
  • Cerebral Cortex
  • Ephrin-A4
  • Ephrin-A5
  • Female
  • Ligands
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neural Pathways
  • Receptor, EphA4
  • Receptor, EphA5
  • Thalamus
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Identity

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(03)00440-9

PubMed ID

  • 12895420
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Additional Document Info

start page

  • 453

end page

  • 465

volume

  • 39

issue

  • 3

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