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Suppression of the cytotoxic T cell response to minor alloantigens in vivo. Linked recognition by suppressor T cells

Academic Article
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Overview

authors

  • Gascoigne, Nicholas
  • Crispe, I. N.

publication date

  • 1984

journal

  • European Journal of Immunology  Journal

abstract

  • This report describes the activity of transferable suppressor T cells (Ts) generated in vivo in response to minor alloantigens. These Ts cells are antigen specific in both primary and secondary in vivo cytotoxic T lymphocyte responses to minor alloantigens and are the result of a host response rather than of a graft-vs.-host reaction. The Ts cells are produced soon after immunization and their activity is transient. They act via "linked recognition", since they can suppress the cytotoxic T lymphocyte response to noncross-reactive minor antigens, but only if these are presented on the same antigenic cell. A model for dominant low responsiveness in (high X low responder)F1 animals is proposed, whereby Ts cells, activated via the low responder allele, work by linked recognition to suppress helper cells activated via the high responder allele.

subject areas

  • Animals
  • Cross Reactions
  • Cytotoxicity, Immunologic
  • Epitopes
  • Genetic Linkage
  • Isoantigens
  • Kinetics
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred CBA
  • Minor Histocompatibility Loci
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes, Regulatory
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830140303

PubMed ID

  • 6200331
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Additional Document Info

start page

  • 210

end page

  • 215

volume

  • 14

issue

  • 3

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