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Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice

Academic Article
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Overview

authors

  • Bottomly, K.
  • Mathieson, B. J.
  • Mosier, Donald

publication date

  • 1978

journal

  • Journal of Experimental Medicine  Journal

abstract

  • An adoptive secondary antibody response to phosphorylcholine (PC) can be generated by the transfer of keyhole limpet hemocyanin (KLH)-primed T cells, PC-bovine gamma globulin-primed B cells, and PC-KLH into irradiated syngeneic BALB/c mice. If the KLH-primed T-cell donors were pretreated with anti-idiotype antibodies directed against the BALB/c PC-binding myeloma TEPC 15, their T cells were unable to collaborate effectively with PC-primed B cells; moreover, they could suppress the helper activity of T cells from normal mice for the PC-KLH response. The Ly phenotype of these T cells was found to be Ly 1-, 2+. The specificity of the suppressor T-cell population induced by anti-T15 treatment appears to be both for idiotype (hapten) and carrier, since the suppressor T cells fail to interfere with the antibody response to PC on a heterologous carrier, nor do they suppress the response to trinitrophenol-KLH.

subject areas

  • Animals
  • Antibodies, Anti-Idiotypic
  • Antigens, Surface
  • B-Lymphocytes
  • Choline
  • Hemocyanin
  • Immunoglobulin Idiotypes
  • Immunologic Memory
  • Immunosuppression
  • Lymphocyte Cooperation
  • Mice
  • Mice, Inbred BALB C
  • Phenotype
  • Phosphorylcholine
  • T-Lymphocytes
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Identity

PubMed Central ID

  • PMC2185045

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.148.5.1216

PubMed ID

  • 309912
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Additional Document Info

start page

  • 1216

end page

  • 1227

volume

  • 148

issue

  • 5

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