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Incorporation of nonnatural amino acids into proteins

Academic Article
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Overview

authors

  • Hendrickson, T. L.
  • de Crecy-Lagard, V.
  • Schimmel, Paul

publication date

  • 2004

journal

  • Annual Review of Biochemistry  Journal

abstract

  • The genetic code is established by the aminoacylation of transfer RNA, reactions in which each amino acid is linked to its cognate tRNA that, in turn, harbors the nucleotide triplet (anticodon) specific to the amino acid. The accuracy of aminoacylation is essential for building and maintaining the universal tree of life. The ability to manipulate and expand the code holds promise for the development of new methods to create novel proteins and to understand the origins of life. Recent efforts to manipulate the genetic code have fulfilled much of this potential. These efforts have led to incorporation of nonnatural amino acids into proteins for a variety of applications and have demonstrated the plausibility of specific proposals for early evolution of the code.

subject areas

  • Amino Acids
  • Amino Acyl-tRNA Synthetases
  • Cysteine
  • Evolution, Molecular
  • Genetic Code
  • History, 20th Century
  • In Vitro Techniques
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • Proteins
  • RNA, Catalytic
  • RNA, Transfer, Amino Acyl
  • Research
  • Signal Transduction
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Research

keywords

  • aminoacyl-tRNA synthetase
  • orthogonal
  • protein biosynthesis
  • suppression
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Identity

International Standard Serial Number (ISSN)

  • 0066-4154

Digital Object Identifier (DOI)

  • 10.1146/annurev.biochem.73.012803.092429

PubMed ID

  • 15189139
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Additional Document Info

start page

  • 147

end page

  • 176

volume

  • 73

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